Drug self-administration and ultrasonic vocalizations (USV) are used as behavioral assessments in animal research, but rarely in combination. The purpose of this article is to describe the advantages of recording USVs during drug self-administration procedures to assess affective responses to drug experience.
Maier, E. Y., Ma, S. T., Ahrens, A., Schallert, T. J., Duvauchelle, C. L. Assessment of Ultrasonic Vocalizations During Drug Self-administration in Rats. J. Vis. Exp. (41), e2041, doi:10.3791/2041 (2010).