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神経科学
A 3D Blood-Brain Barrier Model Derived from Human Pluripotent Stem-Cells

A 3D Blood-Brain Barrier Model Derived from Human Pluripotent Stem-Cells

October 20, 2023

Author Spotlight: A Personalized Approach Towards Investigating Alzheimer's Disease Using an In Vitro Blood-Brain Barrier Model

02:09 min
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1,191 Views

Preparing Cells to Assemble a 3D Human-Stem-Cell-Derived In Vitro Blood Brain Barrier

02:05 min
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102 Views

Constructing the 3D Human-Stem-Cell-Derived In Vitro Blood Brain Barrier

02:08 min
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86 Views
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1Icahn School of Medicine at Mount Sinai, 2Black Family Stem Cell Institute at Mount Sinai, 3Ronald M. Loeb Center for Alzheimer’s Disease at Mount Sinai, 4Friedman Brain Institute at Mount Sinai, 5Nash Family Department of Neuroscience at Mount Sinai

概要

The blood-brain barrier (BBB) has a crucial role in sustaining a stable and healthy brain environment. BBB dysfunction is associated with many neurological diseases. We have developed a 3D, stem-cell-derived model of the BBB to investigate cerebrovascular pathology, BBB integrity, and how the BBB is altered by genetics and disease.

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