Reconstruction of the Blood-Brain Barrier <em>In Vitro</em> to Model and Therapeutically Target Neurological Disease

Camille Goldman; Natalie Suhy; Jessica E. Schwarz; Emily Ruth Sartori; Rikki B. Rooklin; Braxton R. Schuldt; Louise A. Mesentier-Louro; Joel W. Blanchard

doi:10.3791/65921

Journal

Neurosciences

A 3D Blood-Brain Barrier Model Derived from Human Pluripotent Stem-Cells

October 20, 2023

Author Spotlight: A Personalized Approach Towards Investigating Alzheimer's Disease Using an In Vitro Blood-Brain Barrier Model

02:09 min

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1,135 Views

Preparing Cells to Assemble a 3D Human-Stem-Cell-Derived In Vitro Blood Brain Barrier

02:05 min

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98 Views

Constructing the 3D Human-Stem-Cell-Derived In Vitro Blood Brain Barrier

02:08 min

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77 Views

Camille Goldman*^1,2,3,4,5, Natalie Suhy*^1,2,3,4,5, Jessica E. Schwarz^1,2,3,4,5, Emily Ruth Sartori^1,2,3,4,5, Rikki B. Rooklin^1,2,3,4,5, Braxton R. Schuldt^1,2,3,4,5, Louise A. Mesentier-Louro^1,2,3,4,5, Joel W. Blanchard^1,2,3,4,5

¹Icahn School of Medicine at Mount Sinai, ²Black Family Stem Cell Institute at Mount Sinai, ³Ronald M. Loeb Center for Alzheimer’s Disease at Mount Sinai, ⁴Friedman Brain Institute at Mount Sinai, ⁵Nash Family Department of Neuroscience at Mount Sinai

Summary

The blood-brain barrier (BBB) has a crucial role in sustaining a stable and healthy brain environment. BBB dysfunction is associated with many neurological diseases. We have developed a 3D, stem-cell-derived model of the BBB to investigate cerebrovascular pathology, BBB integrity, and how the BBB is altered by genetics and disease.

A 3D Blood-Brain Barrier Model Derived from Human Pluripotent Stem-Cells

Author Spotlight: A Personalized Approach Towards Investigating Alzheimer's Disease Using an In Vitro Blood-Brain Barrier Model

Preparing Cells to Assemble a 3D Human-Stem-Cell-Derived In Vitro Blood Brain Barrier

Constructing the 3D Human-Stem-Cell-Derived In Vitro Blood Brain Barrier

Summary

Article