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Quantifying DNA Double Strand Break Repair with Nanoluciferase Reporter Assays
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Author Spotlight: Developing Novel Anticancer Therapeutics Targeting the DNA Damage Response
JoVE Journal
Ricerca sul cancro
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JoVE Journal Ricerca sul cancro
Assessment of DNA Double Strand Break Repair Activity Using High-throughput and Quantitative Luminescence-Based Reporter Assays

Author Spotlight: Developing Novel Anticancer Therapeutics Targeting the DNA Damage Response

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01:41 min

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June 14, 2024

DOI:

10.3791/66969-v

DOI:
10.3791/66969-v

•

01:41 min
June 14, 2024

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20 Views
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1Artios Pharma Ltd, Cambridge, 2The Francis Crick Institute, London

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Ricerca sul cancroNon-homologous End JoiningMicrohomology-mediated End JoiningSingle Strand AnnealingNanoluciferase Reporter AssayHigh-throughput ScreeningDNA Repair ResearchDrug Discovery

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Grande, D., Rajendra, E., Mason, B., Galbiati, A., Boulton, S. J., Smith, G. C. M., Robinson, H. M. R. Assessment of DNA Double Strand Break Repair Activity Using High-throughput and Quantitative Luminescence-Based Reporter Assays. J. Vis. Exp. (208), e66969, doi:10.3791/66969 (2024).

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