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Bioengineering

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JoVE Journal Bioengineering
Evaluation of Cardiac Contractility Modulation Therapy in 2D Human Stem Cell-Derived Cardiomyocytes
 

Evaluation of Cardiac Contractility Modulation Therapy in 2D Human Stem Cell-Derived Cardiomyocytes

Article DOI: 10.3791/64848-v • 08:47 min • December 16th, 2022
December 16th, 2022 •
1, 1, 1, 1
1Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, U.S. Food and Drug Administration

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Here, we demonstrate a non-invasive cardiac medical device contractility evaluation method using 2D human induced pluripotent stem cell-derived cardiomyocyte (hiPSC-CM) monolayers, plated on a flexible substrate, coupled with video-based microscopy. This tool will be useful for the in vitro evaluation of the contractile properties of cardiac electrophysiology devices.

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Cardiac Contractility Modulation Therapy 2D Human Stem Cell-Derived Cardiomyocytes Medical Device Developers FDA Reviewers Regulatory Science Tools Patient Access To Medical Devices Induced Pluripotent Stem Cell Technology Assessment Of Medical Devices Life-threatening Cardiac Conditions Cardiac Electrophysiology Devices Human IPSC Derived Cardiomyocytes Flexible Hydrogel Substrate Standard Cardiomyocyte Medium Cryo-preservation Viability And Stable Beating DPBS Without Calcium Chloride
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