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A Procedure to Study Stress-Induced Relapse of Heroin Seeking after Punishment-Imposed Abstinence
JoVE Journal
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A Procedure to Study Stress-Induced Relapse of Heroin Seeking after Punishment-Imposed Abstinence

A Procedure to Study Stress-Induced Relapse of Heroin Seeking after Punishment-Imposed Abstinence

2,364 Views

08:05 min

March 23, 2022

DOI:

08:05 min
March 23, 2022

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Summary

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A procedure that demonstrates a robust acute food deprivation-induced relapse to heroin seeking after punishment-imposed abstinence is described. A punishment-imposed abstinence model was successfully implemented using the seek and take chain schedule for heroin self-administration. Heroin-seeking tests are then performed following 24 h of food-deprivation stress.

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