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A Drosophila Model to Study Wound-induced Polyploidization
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Biologia dello sviluppo
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JoVE Journal Biologia dello sviluppo
A Drosophila Model to Study Wound-induced Polyploidization

A Drosophila Model to Study Wound-induced Polyploidization

5,018 Views

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07:27 min

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June 09, 2020

DOI:

10.3791/61252-v

DOI:
10.3791/61252-v

•

07:27 min
June 09, 2020

•

12 Views
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1Biology Department,Boston College, 2Graduate School of Biomedical Sciences and Engineering and Kathryn W. Davis Center for Regenerative Biology and Medicine, MDI Biological Laboratory,University of Maine

Summary

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Wound-induced polyploidization is a conserved tissue repair strategy where cells grow in size instead of dividing to compensate for cell loss. Here is a detailed protocol on how to use the fruit fly as a model to measure ploidy and its genetic regulation in epithelial wound repair.

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Cite this Article

Bailey, E. C., Dehn, A. S., Gjelsvik, K. J., Besen-McNally, R., Losick, V. P. A Drosophila Model to Study Wound-induced Polyploidization. J. Vis. Exp. (160), e61252, doi:10.3791/61252 (2020).

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