This article presents an efficient method to perform myocardial ischemia and subsequent chronic reperfusion in rats using a minimally invasive approach. In addition, left ventricular hemodynamic function of rats is assessed by echocardiography and isolated working heart methods.
Pilz, P. M., Lang, M., Hamza, O., Szabo, P. L., Inci, M., Kramer, A. M., Koch, M., Huber, J., Podesser, B. K., Kiss, A. Semi-Minimal Invasive Method to Induce Myocardial Infarction in Rats and the Assessment of Cardiac Function by an Isolated Working Heart System. J. Vis. Exp. (160), e61033, doi:10.3791/61033 (2020).