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Translaminar Autonomous System Model for the Modulation of Intraocular and Intracranial Pressure in Human Donor Posterior Segments
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JoVE Journal Neuroscienze
Translaminar Autonomous System Model for the Modulation of Intraocular and Intracranial Pressure in Human Donor Posterior Segments

Translaminar Autonomous System Model for the Modulation of Intraocular and Intracranial Pressure in Human Donor Posterior Segments

DOI:
10.3791/61006-v

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08:55 min

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April 24, 2020

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, , ,
1North Texas Eye Research Institute, Department of Pharmacology and Neuroscience,University of North Texas Health Science Center, 2Mechanical Engineer Consultant, 3Department of Ophthalmology and Visual Sciences, School of Medicine and Public Health,University of Wisconsin

Capitoli

  • 00:05Introduction
  • 00:44Translaminar Autonomous System (TAS) Setup
  • 01:42Human Whole Eye Globe Preparation
  • 02:24IOP (Bottom) Chamber Setup
  • 03:20ICP (Top) Chamber Setup
  • 03:52Data Recording System Setup
  • 06:56Results: Representative Translaminar Autonomous System Model Analyses
  • 08:26Conclusion

Summary

Traduzione automatica

Traduzione automatica

We describe and detail the use of the translaminar autonomous system. This system utilizes the human posterior segment to independently regulate the pressure inside the segment (intraocular) and surrounding the optic nerve (intracranial) to generate a translaminar pressure gradient that mimics features of glaucomatous optic neuropathy.

Tags

Keywords: Translaminar Autonomous SystemIntraocular PressureIntracranial PressurePosterior SegmentEx VivoPreclinicalGlaucomaTraumatic Brain InjuryIdiopathic Intracranial HypertensionSpaceflight-associated Neuro-ocular SyndromePerfusion FluidSyringeFilterTubingOptic NerveVitreous HumorRetinaEpoxy ResinO-ringScrewsIOP Chamber

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