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An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause
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Capitoli
- 00:05Titolo
- 00:52Bilateral Ovariectomy
- 02:22Body Weight, Total Cholesterol (TC), and Triglyceride (TG) Measurement
- 03:25Aorta Harvest
- 04:29Results: Representative Effects of Exogenous Estrogens on OVX Mouse Phenotype and Function
- 05:46Conclusion
Clinically, estrogen deficiency in menopausal women may aggravate the incidence of lipid disruption and atherosclerosis. We established an in vivo estrogen deficiency model by bilateral ovariectomy via a double dorsal-lateral incision in apoE-/- mice. The mouse model is applicable for screening exogenous estrogen treatments of cardiovascular dysfunction after menopause.
