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Cell-based Assay to Study Antibody-mediated Tau Clearance by Microglia
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November 09, 2018
DOI:
1Neuroscience Discovery,Janssen Pharmaceutical Company of Johnson & Johnson, Belgium, 2Department of Hematopoiesis,Sanquin Research and Landsteiner Laboratory, The Netherlands, 3Janssen Prevention Center,Janssen Pharmaceutical Company of Johnson & Johnson, The Netherlands, 4Neuroscience Discovery,Janssen Pharmaceutical Company of Johnson & Johnson, Pennsylvania
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Here we describe a cell-based assay to quantitatively assess tau uptake by microglia with the aim of creating an investigational tool to better characterize the mechanisms of action of anti-tau antibodies.
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De Marco, D., Taggenbrock, R., Crespo, R., Koudstaal, W., Ramsburg, E., Apetri, A. Cell-based Assay to Study Antibody-mediated Tau Clearance by Microglia. J. Vis. Exp. (141), e58576, doi:10.3791/58576 (2018).
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