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Neuroscience

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JoVE Journal Neuroscience
Generation and On-Demand Initiation of Acute Ictal Activity in Rodent and Human Tissue
 

Generation and On-Demand Initiation of Acute Ictal Activity in Rodent and Human Tissue

Article DOI: 10.3791/57952-v • 06:45 min • January 19th, 2019
January 19th, 2019 •
1,2, 1,3, 1,2,3,5,6, 1,2,3,4
1Division of Fundamental Neurobiology, Krembil Research Institute, 2Institute of Medical Science, Faculty of Medicine, University of Toronto, 3Institute of Biomaterials and Biomedical Engineering, University of Toronto, 4Division of Neurosurgery, Department of Surgery, University of Toronto, 5Division of Neurology, Department of Medicine, University of Toronto, 6Department of Physiology, University of Toronto

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Acute seizure models are important for studying the mechanisms underlying epileptiform events. Furthermore, the ability to generate epileptiform events on-demand provides a highly efficient method to study the exact sequence of events underlying their initiation. Here, we describe the acute 4-aminopyridine cortical seizure models established in mouse and human tissue.

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Keywords: Acute Ictal Activity Seizure Mechanisms Electrographic Seizure Anti-seizure Therapies Cortical Slices Brain Tissue Vibratome Dissection Solution ACSF Incubation Chamber Electrophysiological Recordings
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