We present a protocol to utilize the Madagascar hissing cockroach as an alternative non-mammalian animal model to conduct bacterial virulence, pathogenesis, drug toxicity, drug efficacy, and innate immune response studies.
Chua, J., Fisher, N. A., Falcinelli, S. D., DeShazer, D., Friedlander, A. M. The Madagascar Hissing Cockroach as an Alternative Non-mammalian Animal Model to Investigate Virulence, Pathogenesis, and Drug Efficacy. J. Vis. Exp. (129), e56491, doi:10.3791/56491 (2017).