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Failure of Cleaning Verification in Pharmaceutical Industry Due to Uncleanliness of Stainless Steel Surface
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JoVE Journal Chimica
Failure of Cleaning Verification in Pharmaceutical Industry Due to Uncleanliness of Stainless Steel Surface

Failure of Cleaning Verification in Pharmaceutical Industry Due to Uncleanliness of Stainless Steel Surface

DOI:
10.3791/56175-v

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07:00 min

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August 11, 2017

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,
1Analytical Research and Development,Novartis Pharmaceuticals Corporation

Capitoli

  • 00:05Titolo
  • 00:46Sample Solution and Coupons Cleaning
  • 02:02Swabbing Procedure
  • 04:07Recovery Calculation
  • 04:46Influence of Coupon Cleaning on Recovery Results
  • 06:11Conclusion

Summary

Traduzione automatica

Traduzione automatica

The lack of a well-defined procedure that consistently cleaned coupon surfaces was identified as the major contributor to low and variable recoveries in cleaning verification. This manuscript describes the correct protocol of cleaning stainless steel coupons.

Tags

Cleaning VerificationPharmaceutical IndustryStainless Steel SurfaceAnalytical Method DevelopmentCleaning LimitCleaning ApproachHPLC WaterAlkaline DetergentAcid DetergentSwabbingDrug Residue Recovery

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