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Immunology and Infection

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JoVE Journal Immunology and Infection
Come to the Light Side
 

Come to the Light Side: In Vivo Monitoring of Pseudomonas aeruginosa Biofilm Infections in Chronic Wounds in a Diabetic Hairless Murine Model

Article DOI: 10.3791/55991-v • 09:15 min • October 10th, 2017
October 10th, 2017 •
1, 1, 1, 2, 2, 2, 1
1Department of Microbiology and Molecular Genetics, Michigan State University, 2Department of Physiology, Michigan State University

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Here we describe a novel diabetic murine model utilizing hairless mice for real-time, non-invasive, monitoring of biofilm wound infections of bioluminescent Pseudomonas aeruginosa. This method can be adapted to evaluate infection of other bacterial species and genetically modified microorganisms, including multi-species biofilms, and test the efficacy of antibiofilm strategies.

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In Vivo Monitoring Pseudomonas Aeruginosa Biofilm Infections Chronic Wounds Diabetic Hairless Murine Model Wound Healing Diabetes In Vivo Biofilm Progression Wound Closure Therapies For Chronic Wounds Systemic Drugs Topical Treatments Antimicrobial Dressings Svetlana Navitskaya Busik Lab Cassie Larrivee Michigan State University Sandra O'Reilly SKH-1 Mice Streptozotocin Hyperglycemia Glucometer
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