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Inyección de raíz dorsal ganglio de raíz dorsal y Lesión por aplastamiento como modelo para la regeneración del axón sensorial
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Neuroscienze
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JoVE Journal Neuroscienze
Dorsal Root Ganglion Injection and Dorsal Root Crush Injury as a Model for Sensory Axon Regeneration
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Inyección de raíz dorsal ganglio de raíz dorsal y Lesión por aplastamiento como modelo para la regeneración del axón sensorial

16,753 Views

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09:48 min

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May 03, 2017

DOI:

10.3791/55535-v

DOI:
10.3791/55535-v

•

09:48 min
May 03, 2017

•

80 Views
, ,
1John van Geest Center for Brain Repair,University of Cambridge, 2School of Medicine,University of St. Andrews, 3Department of Biological Sciences,University of Southampton

Summary

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This protocol presents the use of a dorsal root ganglion (DRG) injection with a viral vector and a concurrent dorsal root crush injury in an adult rat as a model to study sensory axon regeneration. This model is suitable for investigating the use of gene therapy to promote sensory axon regeneration.

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Cheah, M., Fawcett, J. W., Andrews, M. R. Dorsal Root Ganglion Injection and Dorsal Root Crush Injury as a Model for Sensory Axon Regeneration. J. Vis. Exp. (123), e55535, doi:10.3791/55535 (2017).

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