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JoVE Journal Neuroscience
Dorsal Root Ganglion Injection and Dorsal Root Crush Injury as a Model for Sensory Axon Regeneration
 

Dorsal Root Ganglion Injection and Dorsal Root Crush Injury as a Model for Sensory Axon Regeneration

Article DOI: 10.3791/55535-v • 09:48 min • May 3rd, 2017
May 3rd, 2017 •
1, 1, 2,3
1John van Geest Center for Brain Repair, University of Cambridge, 2School of Medicine, University of St. Andrews, 3Department of Biological Sciences, University of Southampton

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résumé
Automatic Translation

This protocol presents the use of a dorsal root ganglion (DRG) injection with a viral vector and a concurrent dorsal root crush injury in an adult rat as a model to study sensory axon regeneration. This model is suitable for investigating the use of gene therapy to promote sensory axon regeneration.

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Dorsal Root Ganglion Injection Dorsal Root Crush Injury Sensory Axon Regeneration Surgical Approach Therapeutic Intervention Axon Regeneration Central Nervous System Spinal Cord Animal Welfare Anesthetizing Surgical DRG Injection Shave The Fur Disinfect Saline Injection Analgesic Antibiotic Spinal Stereotaxic Frame Heating Pad
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