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Évaluation de l'efficacité et la toxicité des ARNs Ciblage VIH-1 Production pour utilisation en thérapie génique ou des médicaments
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Immunologia e infezioni
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JoVE Journal Immunologia e infezioni
Evaluation of the Efficacy And Toxicity of RNAs Targeting HIV-1 Production for Use in Gene or Drug Therapy
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Évaluation de l'efficacité et la toxicité des ARNs Ciblage VIH-1 Production pour utilisation en thérapie génique ou des médicaments

7,714 Views

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12:03 min

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September 05, 2016

DOI:

10.3791/54486-v

DOI:
10.3791/54486-v

•

12:03 min
September 05, 2016

•

4 Views
, , , ,
1Virus-Cell Interactions Laboratory,Lady Davis Institute for Medical Research, 2Department of Microbiology & Immunology,McGill University, 3Department of Medicine,McGill University

Summary

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Methods to evaluate the efficacy and toxicity of RNA molecules targeting post-integration steps of the HIV-1 replication cycle are described. These methods are useful for screening new molecules and optimizing the format of existing ones.

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Scarborough, R. J., Adams, K. L., Del Corpo, O., Daher, A., Gatignol, A. Evaluation of the Efficacy And Toxicity of RNAs Targeting HIV-1 Production for Use in Gene or Drug Therapy. J. Vis. Exp. (115), e54486, doi:10.3791/54486 (2016).

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