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Adenovirale Terapia genica per diabetici cheratopatia: Effetti sulla guarigione delle ferite e Stem Cell Marker Expression in Human Organ cornee-coltura e le cellule epiteliali Limbal
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Biologia dello sviluppo
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JoVE Journal Biologia dello sviluppo
Adenoviral Gene Therapy for Diabetic Keratopathy: Effects on Wound Healing and Stem Cell Marker Expression in Human Organ-cultured Corneas and Limbal Epithelial Cells
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Adenovirale Terapia genica per diabetici cheratopatia: Effetti sulla guarigione delle ferite e Stem Cell Marker Expression in Human Organ cornee-coltura e le cellule epiteliali Limbal

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11:13 min

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April 07, 2016

DOI:

10.3791/54058-v

DOI:
10.3791/54058-v

•

11:13 min
April 07, 2016

•

2 Views
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1Eye Program, Board of Governors Regenerative Medicine Institute, Departments of Biomedical Sciences and Neurosurgery,Cedars-Sinai Medical Center, 2David Geffen School of Medicine,University of California, Los Angeles

Summary

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An example of adenoviral gene therapy in the human diabetic organ-cultured corneas is presented towards the normalization of delayed wound healing and markedly reduced epithelial stem cell marker expression in these corneas. It also describes the optimization of this process in stem cell-enriched limbal epithelial cultures.

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Adenoviral Gene TherapyDiabetic KeratopathyWound HealingStem Cell Marker ExpressionHuman Organ-cultured CorneasLimbal Epithelial CellsEpithelial Wound HealingCorneal Stem Cell FunctionCorneal DiseasesStem Cell DysfunctionEpithelial DebridementCorneal HealingApoptotic Stromal Keratocytes

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Kramerov, A. A., Saghizadeh, M., Ljubimov, A. V. Adenoviral Gene Therapy for Diabetic Keratopathy: Effects on Wound Healing and Stem Cell Marker Expression in Human Organ-cultured Corneas and Limbal Epithelial Cells. J. Vis. Exp. (110), e54058, doi:10.3791/54058 (2016).

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