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A Method for Remotely Silencing Neural Activity in Rodents During Discrete Phases of Learning
 

A Method for Remotely Silencing Neural Activity in Rodents During Discrete Phases of Learning

Article DOI: 10.3791/52859-v • 09:22 min • June 22nd, 2015
June 22nd, 2015 •
1, 1
1Department of Neuroscience, Oberlin College

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This protocol describes how to temporarily and remotely silence neuronal activity in discrete brain regions while rats are engaged in learning and memory tasks. The approach combines pharmacogenetics (Designer-Receptors-Exclusively-Activated-by-Designer-Drugs) with a behavioral paradigm (sensory preconditioning) that is designed to distinguish between different components of learning.

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Remotely Silencing Neural Activity Rodents Discrete Phases Of Learning Pharmacogenetics Designer-Receptors-Exclusively-Activated-by-Designer-Drugs Behavioral Paradigm Sensory Preconditioning Genetically Modified Inhibitory G-protein Coupled Receptor Viral-mediated Delivery Designer Receptor Pharmacological Agent Designer Drug Brain Region Inhibition Of Neurons Biologically Inert Brain Tissue Assessment Specific Components Of Behavior
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