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A Simple and Inexpensive Method for Determining Cold Sensitivity and Adaptation in Mice
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Neuroscienze
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JoVE Journal Neuroscienze
A Simple and Inexpensive Method for Determining Cold Sensitivity and Adaptation in Mice

A Simple and Inexpensive Method for Determining Cold Sensitivity and Adaptation in Mice

14,460 Views

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08:35 min

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March 17, 2015

DOI:

10.3791/52640-v

DOI:
10.3791/52640-v

•

08:35 min
March 17, 2015

•

10 Views
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1MSTP, Neuroscience Program,Washington University in St. Louis, 2Washington University Pain Center, Department of Anesthesiology,Washington University in St. Louis

Summary

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The Cold Plantar Assay (CPA) measures cold responsiveness between 30 °C and 5 °C, and can also measure cold adaptation. This protocol describes how to use the CPA to measure cold hypersensitivity, analgesia, and adaptation in mice.

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Cold SensitivityCold HypersensitivityCold Plantar AssayCold AdaptationThermal ResponseCold AnalgesiaCold NociceptionMouse BehaviorTemperature Sensitivity

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Cite this Article

Brenner, D. S., Golden, J. P., Vogt, S. K., Gereau IV, R. W. A Simple and Inexpensive Method for Determining Cold Sensitivity and Adaptation in Mice. J. Vis. Exp. (97), e52640, doi:10.3791/52640 (2015).

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