The goal of this manuscript is to study the hippocampus and hippocampal subfields using MRI. The manuscript describes a protocol for segmenting the hippocampus and five hippocampal substructures: cornu ammonis (CA) 1, CA2/CA3, CA4/dentate gyrus, strata radiatum/lacunosum/moleculare, and subiculum.
Winterburn, J., Pruessner, J. C., Sofia, C., Schira, M. M., Lobaugh, N. J., Voineskos, A. N., Chakravarty, M. M. High-resolution In Vivo Manual Segmentation Protocol for Human Hippocampal Subfields Using 3T Magnetic Resonance Imaging. J. Vis. Exp. (105), e51861, doi:10.3791/51861 (2015).