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JoVE Journal Neuroscience
High-resolution In Vivo Manual Segmentation Protocol for Human Hippocampal Subfields Using 3T Magnetic Resonance Imaging
 

High-resolution In Vivo Manual Segmentation Protocol for Human Hippocampal Subfields Using 3T Magnetic Resonance Imaging

Article DOI: 10.3791/51861-v • 11:03 min • November 10th, 2015
November 10th, 2015 •
1,2, 3, 4,5, 6,7, 4,8, 5,9, 1,2
1Institute of Biomaterials and Biomedical Engineering, University of Toronto, 2Computational Brain Anatomy Laboratory, Douglas Institute, McGill University, 3McGill Centre for Studies in Aging, McGill University, 4MRI Unit, Research Imaging Centre, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, 5Department of Psychiatry, University of Toronto, 6School of Psychology, University of Wollongong, 7Neuroscience Research Australia, 8Department of Medicine, University of Toronto, 9Kimel Family Translational Imaging Genetics Research Laboratory, Research Imaging Centre, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health

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résumé
Automatic Translation

The goal of this manuscript is to study the hippocampus and hippocampal subfields using MRI. The manuscript describes a protocol for segmenting the hippocampus and five hippocampal substructures: cornu ammonis (CA) 1, CA2/CA3, CA4/dentate gyrus, strata radiatum/lacunosum/moleculare, and subiculum.

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High-resolution In Vivo Manual Segmentation Human Hippocampal Subfields 3T Magnetic Resonance Imaging Memory Brain Function Neuropsychiatric Disorders Neuroanatomical Structure Specialized Functions Disease States Morphology Advanced Imaging Software Research And Clinical Imaging Centers Anterior-posterior Length Cornu Ammonis (CA) 1 CA2/CA3 CA4/dentate Gyrus (DG) Strata Radiatum/lacunosum/moleculare (SR/SL/SM) Subiculum Protocol Reliability Dice's Kappa Metric
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