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Creating Dynamic Images of Short-lived Dopamine Fluctuations with lp-ntPET: Dopamine Movies of Cigarette Smoking
JoVE Journal
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JoVE Journal Comportamento
Creating Dynamic Images of Short-lived Dopamine Fluctuations with lp-ntPET: Dopamine Movies of Cigarette Smoking

Creating Dynamic Images of Short-lived Dopamine Fluctuations with lp-ntPET: Dopamine Movies of Cigarette Smoking

18,059 Views

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14:21 min

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August 06, 2013

DOI:

10.3791/50358-v

DOI:
10.3791/50358-v

•

14:21 min
August 06, 2013

•

6 Views
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1Diagnostic Radiology,Yale University, 2Psychiatry,Yale University, 3Yale PET Center,Yale University, 4Biomedical Engineering,Yale University, 5Nuclear Medicine,Massachusetts General Hospital, 6Radiological Sciences,University of California, Irvine

Summary

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We present a novel PET imaging approach for capturing dopamine fluctuations induced by cigarette smoking. Subjects smoke in the PET scanner. Dynamic PET images are modeled voxel-by-voxel in time by lp-ntPET, which includes a time-varying dopamine term. The results are 'movies' of dopamine fluctuations in the striatum during smoking.

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Morris, E. D., Kim, S. J., Sullivan, J. M., Wang, S., Normandin, M. D., Constantinescu, C. C., Cosgrove, K. P. Creating Dynamic Images of Short-lived Dopamine Fluctuations with lp-ntPET: Dopamine Movies of Cigarette Smoking. J. Vis. Exp. (78), e50358, doi:10.3791/50358 (2013).

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