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用いて、化合物の生理活性をスクリーニングするためのペアNanoinjectionと電気生理学的アッセイキイロショウジョウバエジャイアントファイバシステム
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JoVE Journal Neuroscienze
Paired Nanoinjection and Electrophysiology Assay to Screen for Bioactivity of Compounds using the Drosophila melanogaster Giant Fiber System
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用いて、化合物の生理活性をスクリーニングするためのペアNanoinjectionと電気生理学的アッセイキイロショウジョウバエジャイアントファイバシステム

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09:39 min

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April 15, 2012

DOI:

10.3791/3597-v

DOI:
10.3791/3597-v

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09:39 min
April 15, 2012

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, , , ,
1Department of Biological Sciences,Florida Atlantic University, 2Department of Chemistry & Biochemistry,Florida Atlantic University

Tags

NanoinjectionElectrophysiology AssayScreenBioactivityCompoundsDrosophila MelanogasterGiant Fiber SystemIn Vivo ActivityPharmacological AgentsModulatory EffectsNeuronal CircuitSmall MoleculesPeptidesMolecular TargetsGap JunctionsCholinergicNicotinic Acetylcholine ReceptorsNeuromuscular JunctionsGlutamatergicNanoliter QuantitiesIntracellular Recordings

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Mejia, M., Heghinian, M. D., Busch, A., Marí, F., Godenschwege, T. A. Paired Nanoinjection and Electrophysiology Assay to Screen for Bioactivity of Compounds using the Drosophila melanogaster Giant Fiber System. J. Vis. Exp. (62), e3597, doi:10.3791/3597 (2012).

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