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Journal / Medicine / Biomarkers in an Animal Model for Revealing…
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Biomarkers in an Animal Model for Revealing Neural, Hematologic, and Behavioral Correlates of PTSD
 

Biomarkers in an Animal Model for Revealing Neural, Hematologic, and Behavioral Correlates of PTSD

Article DOI: 10.3791/3361-v • 08:29 min • October 10th, 2012
October 10th, 2012 •
1, 2, 1, 1, 1, 2, 1, 1, 2, 1
1Department of Psychiatry, Center for the Study of Traumatic Stress, Uniformed Services University of the Health Sciences, Bethesda, Maryland, 2Department of Gene and Protein Biomarkers, GenProMarkers, Inc.

Capitoli

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We describe a rat model of post traumatic stress disorder (PTSD) that reveals the persistent alterations in neuroendocrine function and the delayed long-term, exaggerated fear response, characteristic of PTSD patients. The animal model and methods described here are useful for correlating biomarkers in brain nuclei, which are mechanistic but cannot be measured in patients, with biomarkers in peripheral white blood cells, which can.

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Biomarkers Animal Model Neural Correlates Hematologic Correlates Behavioral Correlates PTSD Pathophysiology Objective Diagnosis Therapeutic Efficacy Resilience To Trauma Molecular Biomarkers Traumatic Stress Induced Proteins Transcriptomes Genomic Variances Genetic Modulators Biologic Samples Blood Saliva Urine Postmortem Brain Tissues Peripheral Biomarkers Central Biomarkers Behavioral Phenotype Animal Model Of PTSD Restraint And Tail Shocks Model (ITS) Pathophysiology Of PTSD
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