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JoVE Journal Medicine
Evaluation of Cancer Stem Cell Migration Using Compartmentalizing Microfluidic Devices and Live Cell Imaging
 

Evaluation of Cancer Stem Cell Migration Using Compartmentalizing Microfluidic Devices and Live Cell Imaging

Article DOI: 10.3791/3297-v • 09:37 min • December 23rd, 2011
December 23rd, 2011 •
*1,2, *3, 3, 1,2,3, 3,4
1Department of Biomedical Engineering, University of Wisconsin-Madison, 2Materials Science Program, University of Wisconsin-Madison, 3Department of Neurological Surgery, University of Wisconsin-Madison, 4Carbone Comprehensive Cancer Center and Center for Stem Cell and Regenerative Medicine, University of Wisconsin-Madison
* These authors contributed equally

Capitoli

Riepilogo
Automatic Translation

A compartmentalizing microfluidic device for investigating cancer stem cell migration is described. This novel platform creates a viable cellular microenvironment and enables microscopic visualization of live cell locomotion. Highly motile cancer cells are isolated to study molecular mechanisms of aggressive infiltration, potentially leading to more effective future therapies.

Tags

Cancer Stem Cell Migration Compartmentalizing Microfluidic Devices Live Cell Imaging Cancer Research Cellular Migration Aggressive Cancer Cell Invasion Metastasis Therapeutic Resistance Glioblastoma Multiforme (GBM) Primary Malignant Adult Brain Tumor GBM Infiltration Tumor Microenvironment Cancer Cell Migration Mechanisms Brain Tumor Stem Cell (BTSC) Therapeutic Resistance Recurrence Cell Migratory Mechanisms Conventional Migration Assays Microfluidic Devices Single Cell Analysis
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