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含量测定β-淀粉样蛋白的毒性，使用转基因 C。线虫模型

JoVE Journal
Neuroscienze

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JoVE Journal Neuroscienze

Assaying β-amyloid Toxicity using a Transgenic C. elegans Model

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含量测定β-淀粉样蛋白的毒性，使用转基因 C。线虫模型

24,970 Views

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13:59 min

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October 09, 2010

DOI:

DOI:

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13:59 min

October 09, 2010

•

20 Views

Vishantie Dostal¹, Christopher D. Link^1,2

¹Institute for Behavioral Genetics,University of Colorado, ²Integrative Physiology,University of Colorado

Summary

强研究的线虫<em>线虫</em>可transgenically的设计，以表达人类β-淀粉样肽（Aβ）。诱导表达的Aβ<em> C。线虫</em>肌肉导致一个快速，重现性瘫痪的表型，可用于监测治疗，调节Aβ的毒性。

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