Assaying &beta;-amyloid Toxicity using a Transgenic <em>C. elegans</em> Model

Vishantie Dostal; Christopher D. Link

doi:10.3791/2252

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Assaying β-amyloid Toxicity using a Transgenic C. elegans Model

JoVE Journal
Neuroscienze

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JoVE Journal Neuroscienze

Assaying β-amyloid Toxicity using a Transgenic C. elegans Model

Assaying β-amyloid Toxicity using a Transgenic C. elegans Model

24,964 Views

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13:59 min

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October 09, 2010

DOI:

10.3791/2252-v

DOI:

10.3791/2252-v

•

13:59 min

October 09, 2010

•

20 Views

Vishantie Dostal¹, Christopher D. Link^1,2

¹Institute for Behavioral Genetics,University of Colorado, ²Integrative Physiology,University of Colorado

Summary

The intensely studied nematode worm Caenorhabditis elegans can be transgenically engineered to express the human β-amyloid peptide (Aβ). Induced expression of Aβ in C. elegans muscle leads to a rapid, reproducible paralysis phenotype that can be used to monitor treatments that modulate Aβ toxicity.

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Assaying β-amyloid Toxicity using a Transgenic C. elegans Model

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