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Characterization of Ternary Complex Formation in PROTACs Using Biophysical Assays
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Biolayer Interferometry (BLI) for Evaluating PROTACS-Induced Ternary Complex Formation
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Biochimica
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JoVE Journal Biochimica
Biolayer Interferometry (BLI) for Evaluating PROTACS-Induced Ternary Complex Formation

Biolayer Interferometry (BLI) for Evaluating PROTACS-Induced Ternary Complex Formation

Characterization of Ternary Complex Formation in PROTACs Using Biophysical Assays

DOI:
10.3791/200655-v

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01:23 min

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January 12, 2024

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1Center for the Development of Therapeutics,The Broad Institute of MIT and Harvard

Tags

Biolayer InterferometryBLIPROTACSTernary Complex FormationVHLMZ1BRD4Binary ComplexTernary ComplexOn RateOff RateEquilibrium Dissociation Constant

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