Fibroblasts are versatile connective tissue cells that perform diverse functions such as healing wounds, maintaining the extracellular matrix or ECM, and transforming into other connective tissue cells. During wound healing, a blood clot forms, and platelets at the injury site release multiple growth factors. These growth factors activate fibroblasts to transform into myofibroblasts. These cells can proliferate and produce ECM proteins. ECM proteins facilitate wound healing by binding growth factors, directing cytoskeletal reorganization, and degrading other ECM molecules, among other functions. Fibroblasts can transform into different cell types of the connective tissue family. Fibroblasts can transdifferentiate into fat cells, bone cells, or smooth muscle cells based on their physical or chemical environment. Fibroblasts can also be reprogrammed to form induced pluripotent cells, promising tools in regenerative medicine.