Prescription drugs are medications that can only be obtained with a medical practitioner's prescription from a pharmacy. Prescription drugs have various applications ranging from central nervous system depressants that treat pain and anxiety to α and β-blockers that control hypertension. Inappropriate usage of prescription drugs can lead to their misuse and addiction. Nonprescription drugs or over-the-counter drugs are drugs that can be obtained without a prescription. Common nonprescription drugs include ibuprofen, omeprazole, loratadine, and nicotine patches. Orphan drugs are used to treat rare diseases affecting less than 200,000 individuals in the United States. Orphan drugs, such as Velcade, treat amyloidosis, and atiprimod treats multiple myeloma.