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Synthesizing Lipid Nanoparticles Using CIJ and µMIVM Mixer Technologies

Synthesizing Lipid Nanoparticles Using CIJ and µMIVM Mixer Technologies

August 23, 2024

Author Spotlight: Enhancing Lipid Nanoparticle Formation Through Turbulent Mixing in Confined Geometries

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Optimized Formulation of Lipid Nanoparticles Using a Two-Jet Continuous Impinging Jet (CIJ) Mixer

02:23 min
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Advanced Formulation and Production of Lipid Nanoparticles Using a Four-Jet Micro-Size Multiple Inlet Vortex Mixer (µMIVM)

03:20 min
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1Department of Chemical and Biological Engineering,Princeton University

Summary

A detailed protocol for synthesizing lipid nanoparticles (LNPs) using confined impinging jet (CIJ) mixer technologies, including a two-jet CIJ and a four-jet multi-inlet vortex mixer (µMIVM), is demonstrated. The CIJ mixers generate reproducible, turbulent micro-mixing environments, resulting in the production of monodisperse LNPs.

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