Robert F. Margolskee Monell Chemical Senses Center Biography Publications Institution JoVE Articles Robert F. Margolskee has not added a biography. If you are Robert F. Margolskee and would like to personalize this page please email our Author Liaison for assistance. Publications Activation of Intestinal Tuft Cell-expressed Sucnr1 Triggers Type 2 Immunity in the Mouse Small Intestine Proceedings of the National Academy of Sciences of the United States of America. 05, 2018 | Pubmed ID: 29735652 Aggravated Gut Inflammation in Mice Lacking the Taste Signaling Protein α-gustducin Brain, Behavior, and Immunity. Jul, 2018 | Pubmed ID: 29678794 Gli3 is a Negative Regulator of Tas1r3-expressing Taste Cells PLoS Genetics. 02, 2018 | Pubmed ID: 29415007 Bitter Taste Responses of Gustducin-positive Taste Cells in Mouse Fungiform and Circumvallate Papillae Neuroscience. Jan, 2018 | Pubmed ID: 29113930 Bacterial D-amino Acids Suppress Sinonasal Innate Immunity Through Sweet Taste Receptors in Solitary Chemosensory Cells Science Signaling. Sep, 2017 | Pubmed ID: 28874606 Whole Transcriptome Profiling of Taste Bud Cells Scientific Reports. Aug, 2017 | Pubmed ID: 28790351 Transcriptome Analyses of Taste Organoids Reveal Multiple Pathways Involved in Taste Cell Generation Scientific Reports. Jun, 2017 | Pubmed ID: 28638111 Taste Cell-expressed α-glucosidase Enzymes Contribute to Gustatory Responses to Disaccharides Proceedings of the National Academy of Sciences of the United States of America. May, 2016 | Pubmed ID: 27162343 Amiloride-Insensitive Salt Taste Is Mediated by Two Populations of Type III Taste Cells with Distinct Transduction Mechanisms The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Feb, 2016 | Pubmed ID: 26865617 Tuft Cells, Taste-chemosensory Cells, Orchestrate Parasite Type 2 Immunity in the Gut Science (New York, N.Y.). Mar, 2016 | Pubmed ID: 26847546 Functional Analyses of Bitter Taste Receptors in Domestic Cats (Felis Catus) PloS One. 2015 | Pubmed ID: 26488302 Characterization of the Binding Site of Aspartame in the Human Sweet Taste Receptor Chemical Senses. Oct, 2015 | Pubmed ID: 26377607 Sugar-induced Cephalic-phase Insulin Release is Mediated by a T1r2+T1r3-independent Taste Transduction Pathway in Mice American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. Sep, 2015 | Pubmed ID: 26157055 Leptin Suppresses Mouse Taste Cell Responses to Sweet Compounds Diabetes. Nov, 2015 | Pubmed ID: 26116698 Glucagon-like Peptide-1 is Specifically Involved in Sweet Taste Transmission FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Jun, 2015 | Pubmed ID: 25678625 Single Lgr5- or Lgr6-expressing Taste Stem/progenitor Cells Generate Taste Bud Cells Ex Vivo Proceedings of the National Academy of Sciences of the United States of America. Nov, 2014 | Pubmed ID: 25368147 Differential Contribution of TRPM4 and TRPM5 Nonselective Cation Channels to the Slow Afterdepolarization in Mouse Prefrontal Cortex Neurons Frontiers in Cellular Neuroscience. 2014 | Pubmed ID: 25237295 Expression and Nuclear Translocation of Glucocorticoid Receptors in Type 2 Taste Receptor Cells Neuroscience Letters. Jun, 2014 | Pubmed ID: 24814581 The Bamboo-eating Giant Panda (Ailuropoda Melanoleuca) Has a Sweet Tooth: Behavioral and Molecular Responses to Compounds That Taste Sweet to Humans PloS One. 2014 | Pubmed ID: 24671207 Effects of Roux-en-Y Gastric Bypass on Energy and Glucose Homeostasis Are Preserved in Two Mouse Models of Functional Glucagon-like Peptide-1 Deficiency Molecular Metabolism. Apr, 2014 | Pubmed ID: 24634822 Bitter and Sweet Taste Receptors Regulate Human Upper Respiratory Innate Immunity The Journal of Clinical Investigation. Mar, 2014 | Pubmed ID: 24531552 Endocrine Taste Cells The British Journal of Nutrition. Jun, 2014 | Pubmed ID: 24382120 Mouse Nasal Epithelial Innate Immune Responses to Pseudomonas Aeruginosa Quorum-sensing Molecules Require Taste Signaling Components Innate Immunity. Aug, 2014 | Pubmed ID: 24045336 Genetic Loss or Pharmacological Blockade of Testes-expressed Taste Genes Causes Male Sterility Proceedings of the National Academy of Sciences of the United States of America. Jul, 2013 | Pubmed ID: 23818598 Lgr5-EGFP Marks Taste Bud Stem/progenitor Cells in Posterior Tongue Stem Cells (Dayton, Ohio). May, 2013 | Pubmed ID: 23377989 Gustducin Couples Fatty Acid Receptors to GLP-1 Release in Colon American Journal of Physiology. Endocrinology and Metabolism. Mar, 2013 | Pubmed ID: 23341498 The Role of T1r3 and Trpm5 in Carbohydrate-induced Obesity in Mice Physiology & Behavior. Aug, 2012 | Pubmed ID: 22683548 Targeted Taste Cell-specific Overexpression of Brain-derived Neurotrophic Factor in Adult Taste Buds Elevates Phosphorylated TrkB Protein Levels in Taste Cells, Increases Taste Bud Size, and Promotes Gustatory Innervation The Journal of Biological Chemistry. May, 2012 | Pubmed ID: 22442142 Major Taste Loss in Carnivorous Mammals Proceedings of the National Academy of Sciences of the United States of America. Mar, 2012 | Pubmed ID: 22411809 A Conditioned Aversion Study of Sucrose and SC45647 Taste in TRPM5 Knockout Mice Chemical Senses. Jun, 2012 | Pubmed ID: 21987728 Glucose Transporters and ATP-gated K+ (KATP) Metabolic Sensors Are Present in Type 1 Taste Receptor 3 (T1r3)-expressing Taste Cells Proceedings of the National Academy of Sciences of the United States of America. Mar, 2011 | Pubmed ID: 21383163 REEP2 Enhances Sweet Receptor Function by Recruitment to Lipid Rafts The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Oct, 2010 | Pubmed ID: 20943918 Gut T1R3 Sweet Taste Receptors Do Not Mediate Sucrose-conditioned Flavor Preferences in Mice American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. Dec, 2010 | Pubmed ID: 20926763 Gustation Genetics: Sweet Gustducin! Chemical Senses. Sep, 2010 | Pubmed ID: 20660058 Action Potential-enhanced ATP Release from Taste Cells Through Hemichannels Journal of Neurophysiology. Aug, 2010 | Pubmed ID: 20519578 Phenoxy Herbicides and Fibrates Potently Inhibit the Human Chemosensory Receptor Subunit T1R3 Journal of Medicinal Chemistry. Nov, 2009 | Pubmed ID: 19817384 Role of Olfaction in the Conditioned Sucrose Preference of Sweet-ageusic T1R3 Knockout Mice Chemical Senses. Oct, 2009 | Pubmed ID: 19736224 Expression of the Voltage-gated Potassium Channel KCNQ1 in Mammalian Taste Bud Cells and the Effect of Its Null-mutation on Taste Preferences The Journal of Comparative Neurology. Jan, 2009 | Pubmed ID: 19006182 Involvement of T1R3 in Calcium-magnesium Taste Physiological Genomics. Aug, 2008 | Pubmed ID: 18593862 Effects of Taste Signaling Protein Abolishment on Gut Inflammation in an Inflammatory Bowel Disease Mouse Model Ya-Wen Du*1, Qun Liu*1, Xiao-Cui Luo1, Dong-Xiao Zhao1, Jian-Bo Xue1, Pu Feng2, Robert F. Margolskee2, Hong Wang2, Liquan Huang1,2 1College of Life Sciences, Zhejiang University, 2Monell Chemical Senses Center JoVE 58668 Immunologia e infezioni
Effects of Taste Signaling Protein Abolishment on Gut Inflammation in an Inflammatory Bowel Disease Mouse Model Ya-Wen Du*1, Qun Liu*1, Xiao-Cui Luo1, Dong-Xiao Zhao1, Jian-Bo Xue1, Pu Feng2, Robert F. Margolskee2, Hong Wang2, Liquan Huang1,2 1College of Life Sciences, Zhejiang University, 2Monell Chemical Senses Center JoVE 58668 Immunologia e infezioni