Jaap A. Joles Department of Nephrology & Hypertension University Medical Center Utrecht Biography Publications Institution JoVE Articles Jaap A. Joles has not added a biography. If you are Jaap A. Joles and would like to personalize this page please email our Author Liaison for assistance. Publications Comparative Physiology and Hyperuricemia As a Causal Factor for Hypertension Obesity (Silver Spring, Md.). Jun, 2013 | Pubmed ID: 23804295 Can Exercise Partly Cure the Cardio-renal Syndrome? Clinical and Experimental Pharmacology & Physiology. Jun, 2013 | Pubmed ID: 23763456 Ischemia and Reactive Oxygen Species in Sympathetic Hyperactivity States: A Vicious Cycle That Can Be Interrupted by Renal Denervation? Current Hypertension Reports. Jun, 2013 | Pubmed ID: 23754326 Bone Marrow Cell Therapy in Hypertensive Kidney Disease: Contribution to Cardiac Fibrosis? Journal of Hypertension. May, 2013 | Pubmed ID: 23552031 The Nephron Number Counts--from Womb to Tomb Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association. Jun, 2013 | Pubmed ID: 23233524 Haemodynamic Influences on Kidney Oxygenation: Clinical Implications of Integrative Physiology Clinical and Experimental Pharmacology & Physiology. Feb, 2013 | Pubmed ID: 23167537 Healthy Bone Marrow Cells Reduce Progression of Kidney Failure Better Than CKD Bone Marrow Cells in Rats with Established Chronic Kidney Disease Cell Transplantation. 2012 | Pubmed ID: 23231961 Hemizygous Deletion of CTGF/CCN2 Does Not Suffice to Prevent Fibrosis of the Severely Injured Kidney Matrix Biology : Journal of the International Society for Matrix Biology. Sep-Oct, 2012 | Pubmed ID: 23199377 Early Determinants of Cardiovascular Disease Best Practice & Research. Clinical Endocrinology & Metabolism. Oct, 2012 | Pubmed ID: 22980042 Short-term Erythropoietin Treatment Does Not Substantially Modulate Monocyte Transcriptomes of Patients with Combined Heart and Renal Failure PloS One. 2012 | Pubmed ID: 22957013 Target Organ Cross Talk in Cardiorenal Syndrome: Animal Models American Journal of Physiology. Renal Physiology. Nov, 2012 | Pubmed ID: 22914779 FAN1 Mutations Cause Karyomegalic Interstitial Nephritis, Linking Chronic Kidney Failure to Defective DNA Damage Repair Nature Genetics. Aug, 2012 | Pubmed ID: 22772369 Hypertension: Renal Denervation in Chronic Kidney Disease Nature Reviews. Nephrology. Aug, 2012 | Pubmed ID: 22751507 Human Embryonic Mesenchymal Stem Cell-derived Conditioned Medium Rescues Kidney Function in Rats with Established Chronic Kidney Disease PloS One. 2012 | Pubmed ID: 22723882 ACE Inhibition in Anti-Thy1 Glomerulonephritis Limits Proteinuria but Does Not Improve Renal Function and Structural Remodeling Nephron Extra. Jan, 2012 | Pubmed ID: 22479264 HEALTHY BONE MARROW CELLS REDUCE PROGRESSION OF KIDNEY FAILURE BETTER THAN CKD BONE MARROW CELLS IN RATS WITH ESTABLISHED CHRONIC KIDNEY DISEASE Cell Transplantation. Mar, 2012 | Pubmed ID: 22469231 A Novel Approach for Blood Purification: Mixed-matrix Membranes Combining Diffusion and Adsorption in One Step Acta Biomaterialia. Jul, 2012 | Pubmed ID: 22406909 Effect of GFR on Plasma N-terminal Connective Tissue Growth Factor (CTGF) Concentrations American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation. May, 2012 | Pubmed ID: 22342213 Subtotal Nephrectomy Plus Coronary Ligation Leads to More Pronounced Damage in Both Organs Than Either Nephrectomy or Coronary Ligation American Journal of Physiology. Heart and Circulatory Physiology. Feb, 2012 | Pubmed ID: 22140040 Biological and Technical Considerations Regarding the Removal of Bacteriotoxins in Sepsis with Emphasis on Toxic Shock Syndrome Toxin 1 Shock (Augusta, Ga.). Mar, 2012 | Pubmed ID: 22129566 Systemic Arterial and Venous Determinants of Renal Hemodynamics in Congestive Heart Failure Heart Failure Reviews. Mar, 2012 | Pubmed ID: 21553212 Perinatal Exogenous Nitric Oxide in Fawn-hooded Hypertensive Rats Reduces Renal Ribosomal Biogenesis in Early Life Frontiers in Genetics. 2011 | Pubmed ID: 22303348 Expanding the Beneficial Pleiotropic Repertoire of Interleukin-10 Journal of Hypertension. Nov, 2011 | Pubmed ID: 21989379 Atorvastatin Reduces Sympathetic Activity in Patients with Chronic Kidney Disease Journal of Hypertension. Nov, 2011 | Pubmed ID: 21897294 Salt Sensitivity of Blood Pressure: Developmental and Sex-related Effects The American Journal of Clinical Nutrition. Dec, 2011 | Pubmed ID: 21849600 Enhanced Angiotensin II Type 1 Receptor Expression in Leukocytes of Patients with Chronic Kidney Disease European Journal of Pharmacology. Sep, 2011 | Pubmed ID: 21640098 Perinatal Inhibition of NF-kappaB Has Long-term Antihypertensive Effects in Spontaneously Hypertensive Rats Journal of Hypertension. Jun, 2011 | Pubmed ID: 21505356 Crossing Borders: Linking Environmental and Genetic Developmental Factors Microcirculation (New York, N.Y. : 1994). May, 2011 | Pubmed ID: 21418373 Loss of Endogenous Bone Morphogenetic Protein-6 Aggravates Renal Fibrosis The American Journal of Pathology. Mar, 2011 | Pubmed ID: 21356359 Soluble Epoxide Hydrolase in the Generation and Maintenance of High Blood Pressure in Spontaneously Hypertensive Rats American Journal of Physiology. Endocrinology and Metabolism. Apr, 2011 | Pubmed ID: 21266668 Oxidative Stress in Obstructive Nephropathy International Journal of Experimental Pathology. Jun, 2011 | Pubmed ID: 20804541 Involvement of Connective Tissue Growth Factor in Human and Experimental Hypertensive Nephrosclerosis Nephron. Experimental Nephrology. 2011 | Pubmed ID: 20689330 Can Exercise Prevent Preeclampsia? Journal of Hypertension. Dec, 2010 | Pubmed ID: 21266859 The Nitric Oxide Donor Molsidomine Rescues Cardiac Function in Rats with Chronic Kidney Disease and Cardiac Dysfunction American Journal of Physiology. Heart and Circulatory Physiology. Dec, 2010 | Pubmed ID: 20852057 Renal Sinus Adiposity and Hypertension Hypertension. Nov, 2010 | Pubmed ID: 20837879 IFN Gamma-dependent SOCS3 Expression Inhibits IL-6-induced STAT3 Phosphorylation and Differentially Affects IL-6 Mediated Transcriptional Responses in Endothelial Cells American Journal of Physiology. Cell Physiology. Aug, 2010 | Pubmed ID: 20484656 Reduction of Fibrosis-related Arrhythmias by Chronic Renin-angiotensin-aldosterone System Inhibitors in an Aged Mouse Model American Journal of Physiology. Heart and Circulatory Physiology. Aug, 2010 | Pubmed ID: 20435847 Erythropoietin Treatment in Patients with Combined Heart and Renal Failure: Objectives and Design of the EPOCARES Study Journal of Nephrology. Jul-Aug, 2010 | Pubmed ID: 20383871 Perinatal Micronutrient Supplements Ameliorate Hypertension and Proteinuria in Adult Fawn-hooded Hypertensive Rats American Journal of Hypertension. Jul, 2010 | Pubmed ID: 20360751 Renal Proximal Tubular Dysfunction is a Major Determinant of Urinary Connective Tissue Growth Factor Excretion American Journal of Physiology. Renal Physiology. Jun, 2010 | Pubmed ID: 20237235 Renal Glutathione S-transferase Mu Type 1 Expression is Already Reduced in New-born Spontaneously Hypertensive Rats Journal of Hypertension. Mar, 2010 | Pubmed ID: 20160580 Llama Heavy-chain Antibody Fragments Efficiently Remove Toxic Shock Syndrome Toxin 1 from Plasma in Vitro but Not in Experimental Porcine Septic Shock Shock (Augusta, Ga.). Aug, 2010 | Pubmed ID: 20016410 Renal Venous Congestion and Renal Function in Congestive Heart Failure Journal of the American College of Cardiology. Oct, 2009 | Pubmed ID: 19833266 Is Kidney Ischemia the Central Mechanism in Parallel Activation of the Renin and Sympathetic System? Journal of Hypertension. Jul, 2009 | Pubmed ID: 19444143 Taurine: Red Bull or Red Herring? Hypertension. Jun, 2009 | Pubmed ID: 19398654 Consequences of Perinatal Treatment with L-arginine and Antioxidants for the Renal Transcriptome in Spontaneously Hypertensive Rats Pflügers Archiv : European Journal of Physiology. Jul, 2009 | Pubmed ID: 19189121 Increased SOCS Expression in Peripheral Blood Mononuclear Cells of End Stage Renal Disease Patients is Related to Inflammation and Dialysis Modality European Journal of Pharmacology. Jan, 2009 | Pubmed ID: 19041303 Blood Pressure Follows the Kidney: Perinatal Influences on Hereditary Hypertension Organogenesis. Jul, 2008 | Pubmed ID: 19279727 Increased Expression of SOCS3 in Monocytes and SOCS1 in Lymphocytes Correlates with Progressive Loss of Renal Function and Cardiovascular Risk Factors in Chronic Kidney Disease European Journal of Pharmacology. Sep, 2008 | Pubmed ID: 18656467 CTGF Inhibits BMP-7 Signaling in Diabetic Nephropathy Journal of the American Society of Nephrology : JASN. Nov, 2008 | Pubmed ID: 18632843 A Perinatal Nitric Oxide Donor Increases Renal Vascular Resistance and Ameliorates Hypertension and Glomerular Injury in Adult Fawn-hooded Hypertensive Rats American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. Jun, 2008 | Pubmed ID: 18417652 Detection of Basal NO Production in Rat Tissues Using Iron-dithiocarbamate Complexes Nitric Oxide : Biology and Chemistry / Official Journal of the Nitric Oxide Society. Jun, 2008 | Pubmed ID: 18316042 Amelioration of Anti-Thy1-glomerulonephritis by PPAR-gamma Agonism Without Increase of Endothelial Progenitor Cell Homing American Journal of Physiology. Renal Physiology. Feb, 2008 | Pubmed ID: 18077601 Statins and Small GTPases: Koch's Postulates and Chronic Kidney Disease Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association. Feb, 2008 | Pubmed ID: 18032411 Toll-like Receptor 4 Mediates Maladaptive Left Ventricular Remodeling and Impairs Cardiac Function After Myocardial Infarction Circulation Research. Feb, 2008 | Pubmed ID: 18007026 Mixed Proximal and Distal Renal Tubular Acidosis Without Aminoaciduria in a Mare Journal of Veterinary Internal Medicine / American College of Veterinary Internal Medicine. Sep-Oct, 2007 | Pubmed ID: 17939575 Maternal Supplementation with Citrulline Increases Renal Nitric Oxide in Young Spontaneously Hypertensive Rats and Has Long-term Antihypertensive Effects Hypertension. Dec, 2007 | Pubmed ID: 17938381 Technology Insight: Innovative Options for End-stage Renal Disease--from Kidney Refurbishment to Artificial Kidney Nature Clinical Practice. Nephrology. Oct, 2007 | Pubmed ID: 17895933 Protein Restriction in Lactation Confers Nephroprotective Effects in the Male Rat and is Associated with Increased Antioxidant Expression American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. Sep, 2007 | Pubmed ID: 17581837 Met-RANTES Reduces Endothelial Progenitor Cell Homing to Activated (glomerular) Endothelium in Vitro and in Vivo American Journal of Physiology. Renal Physiology. Aug, 2007 | Pubmed ID: 17567937 Transcriptome-based Identification of Pro- and Antioxidative Gene Expression in Kidney Cortex of Nitric Oxide-depleted Rats Physiological Genomics. Jan, 2007 | Pubmed ID: 17047089 Blood Pressure in Mutant Rats Lacking the 5-hydroxytryptamine Transporter Hypertension. Dec, 2006 | Pubmed ID: 17030677 Low Albumin Levels Increase Endothelial NO Production and Decrease Vascular NO Sensitivity Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association. Dec, 2006 | Pubmed ID: 16997846 Erythropoietin and the Cardiorenal Syndrome: Cellular Mechanisms on the Cardiorenal Connectors American Journal of Physiology. Renal Physiology. Nov, 2006 | Pubmed ID: 16885153 Anti-oxidant Sensitivity of Donor Age-related Gene Expression in Cultured Fibroblasts European Journal of Pharmacology. Aug, 2006 | Pubmed ID: 16797527 Role of Circulating Karyocytes in the Initiation and Progression of Atherosclerosis Hypertension. May, 2006 | Pubmed ID: 16520401 Temporal Expression Profile and Distribution Pattern Indicate a Role of Connective Tissue Growth Factor (CTGF/CCN-2) in Diabetic Nephropathy in Mice American Journal of Physiology. Renal Physiology. Jun, 2006 | Pubmed ID: 16380465 Tetrahydrobiopterin, but Not L-arginine, Decreases NO Synthase Uncoupling in Cells Expressing High Levels of Endothelial NO Synthase Hypertension. Jan, 2006 | Pubmed ID: 16344367 In Mice, Proteinuria and Renal Inflammatory Responses to Albumin Overload Are Strain-dependent Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association. Mar, 2006 | Pubmed ID: 16326737 Effects of Gender on Hepatic HMG-CoA Reductase, Cholesterol 7alpha-hydroxylase, and LDL Receptor in Hereditary Analbuminemia American Journal of Physiology. Endocrinology and Metabolism. Dec, 2005 | Pubmed ID: 16030068 Gene Expression of Energy and Protein Metabolism in Hearts of Hypertensive Nitric Oxide- or GSH-depleted Mice European Journal of Pharmacology. Apr, 2005 | Pubmed ID: 15878706 To D or Not to D: Calcitriol and Vascular Calcification in End-stage Renal Disease Journal of Hypertension. May, 2005 | Pubmed ID: 15834277 Resistance to Oxidative Stress by Chronic Infusion of Angiotensin II in Mouse Kidney is Not Mediated by the AT2 Receptor American Journal of Physiology. Renal Physiology. Jun, 2005 | Pubmed ID: 15727990 Nitric Oxide-dependent and Nitric Oxide-independent Transcriptional Responses to High Shear Stress in Endothelial Cells Hypertension. Apr, 2005 | Pubmed ID: 15699468 The Severe Cardiorenal Syndrome: 'Guyton Revisited' European Heart Journal. Jan, 2005 | Pubmed ID: 15615794 Programming Blood Pressure in Adult SHR by Shifting Perinatal Balance of NO and Reactive Oxygen Species Toward NO: the Inverted Barker Phenomenon American Journal of Physiology. Renal Physiology. Apr, 2005 | Pubmed ID: 15547115 The Role of Nitric Oxide in Renal Transplantation Seminars in Nephrology. Jul, 2004 | Pubmed ID: 15252777 Perinatal L-arginine and Antioxidant Supplements Reduce Adult Blood Pressure in Spontaneously Hypertensive Rats Hypertension. Jul, 2004 | Pubmed ID: 15184350 Hypercholesterolemia in Rats Induces Podocyte Stress and Decreases Renal Cortical Nitric Oxide Synthesis Via an Angiotensin II Type 1 Receptor-sensitive Mechanism Journal of the American Society of Nephrology : JASN. Apr, 2004 | Pubmed ID: 15034097 Broadly Altered Gene Expression in Blood Leukocytes in Essential Hypertension is Absent During Treatment Hypertension. May, 2004 | Pubmed ID: 15007037 Causes and Consequences of Increased Sympathetic Activity in Renal Disease Hypertension. Apr, 2004 | Pubmed ID: 14981063 Sympathetic Hyperactivity in Chronic Renal Failure: a Wake-up Call Journal of the American Society of Nephrology : JASN. Mar, 2004 | Pubmed ID: 14978154 Temporary Losartan or Captopril in Young SHR Induces Malignant Hypertension Despite Initial Normotension Kidney International. Feb, 2004 | Pubmed ID: 14717927 Hypoalbuminaemia Enhances the Renal Vasoconstrictor Effect of Lysophosphatidylcholine Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association. Aug, 2003 | Pubmed ID: 12897085 Bone-marrow-derived Cells Contribute to Glomerular Endothelial Repair in Experimental Glomerulonephritis The American Journal of Pathology. Aug, 2003 | Pubmed ID: 12875975 Hypoxanthine Plus Xanthine Oxidase Causes Profound Natriuresis Without Affecting Renal Blood Flow Autoregulation Kidney International. Jul, 2003 | Pubmed ID: 12787413 NO Dependency of RBF and Autoregulation in the Spontaneously Hypertensive Rat American Journal of Physiology. Renal Physiology. Jul, 2003 | Pubmed ID: 12631552 Male Gender Increases Sensitivity to Renal Injury in Response to Cholesterol Loading American Journal of Physiology. Renal Physiology. Apr, 2003 | Pubmed ID: 12488246 Visualizing Tubular Lipid Peroxidation in Intact Renal Tissue in Hypertensive Rats Journal of the American Society of Nephrology : JASN. Dec, 2002 | Pubmed ID: 12444219 Anti-inflammatory Effects of Tetrahydrobiopterin on Early Rejection in Renal Allografts: Modulation of Inducible Nitric Oxide Synthase FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Jul, 2002 | Pubmed ID: 12039851 Proteinuria is Preceded by Decreased Nitric Oxide Synthesis and Prevented by a NO Donor in Cholesterol-fed Rats Kidney International. May, 2002 | Pubmed ID: 11967027 Inducible Nitric Oxide Synthase in Renal Transplantation Kidney International. Mar, 2002 | Pubmed ID: 11849440 5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat Arianne van Koppen1, Marianne C. Verhaar1, Lennart G. Bongartz1, Jaap A. Joles1 1Department of Nephrology & Hypertension, University Medical Center Utrecht JoVE 50398 Medicina
5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat Arianne van Koppen1, Marianne C. Verhaar1, Lennart G. Bongartz1, Jaap A. Joles1 1Department of Nephrology & Hypertension, University Medical Center Utrecht JoVE 50398 Medicina