Clayton E. Mathews Department of Pathology, Immunology, and Laboratory Medicine University of Florida Biography Publications Institution JoVE Articles Clayton E. Mathews has not added a biography. If you are Clayton E. Mathews and would like to personalize this page please email our Author Liaison for assistance. Publications Islet Sympathetic Innervation and Islet Neuropathology in Patients with Type 1 Diabetes Scientific Reports. Mar, 2021 | Pubmed ID: 33753784 Influence of Allotypes on Innate and Adaptive Immune Function in Health and Disease Frontiers in Immunology. 2021 | Pubmed ID: 33717184 Low-dose ATG/GCSF in Established Type 1 Diabetes: A Five-Year Follow-up Report Diabetes. Feb, 2021 | Pubmed ID: 33632742 Mitochondrial Haplogroup G is Associated with Nonalcoholic Fatty Liver Disease, While Haplogroup A Mitigates the Effects of PNPLA3 Endocrinology, Diabetes & Metabolism. Jan, 2021 | Pubmed ID: 33532620 Branched Chain Amino Acids and Carbohydrate Restriction Exacerbate Ketogenesis and Hepatic Mitochondrial Oxidative Dysfunction During NAFLD FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Nov, 2020 | Pubmed ID: 32918763 Comparing Beta Cell Preservation Across Clinical Trials in Recent-Onset Type 1 Diabetes Diabetes Technology & Therapeutics. 12, 2020 | Pubmed ID: 32833543 Lipid Mediators and Biomarkers Associated with Type 1 Diabetes Development JCI Insight. 08, 2020 | Pubmed ID: 32814707 NKG2D Signaling Within the Pancreatic Islets Reduces NOD Diabetes and Increases Protective Central Memory CD8 T-Cell Numbers Diabetes. 08, 2020 | Pubmed ID: 32535552 Disruption of Hepatic One-carbon Metabolism Impairs Mitochondrial Function and Enhances Macrophage Activity in Methionine-choline-deficient Mice The Journal of Nutritional Biochemistry. 07, 2020 | Pubmed ID: 32422424 Innate Inflammation Drives NK Cell Activation to Impair Treg Activity Journal of Autoimmunity. 03, 2020 | Pubmed ID: 32035746 Neutrophil Cytosolic Factor 1 in Dendritic Cells Promotes Autoreactive CD8 T Cell Activation Via Cross-Presentation in Type 1 Diabetes Frontiers in Immunology. 2019 | Pubmed ID: 31118934 Boosting to Amplify Signal with Isobaric Labeling (BASIL) Strategy for Comprehensive Quantitative Phosphoproteomic Characterization of Small Populations of Cells Analytical Chemistry. May, 2019 | Pubmed ID: 30843680 Sixteen Diverse Laboratory Mouse Reference Genomes Define Strain-specific Haplotypes and Novel Functional Loci Nature Genetics. 11, 2018 | Pubmed ID: 30275530 Nanowell-mediated Two-dimensional Liquid Chromatography Enables Deep Proteome Profiling of <1000 Mammalian Cells Chemical Science. Sep, 2018 | Pubmed ID: 30210768 Correction To: Metabolic Abnormalities in the Pathogenesis of Type 1 Diabetes Current Diabetes Reports. 09, 2018 | Pubmed ID: 30173405 Protective Role of Myeloid Cells Expressing a G-CSF Receptor Polymorphism in an Induced Model of Lupus Frontiers in Immunology. 2018 | Pubmed ID: 29868014 Abnormal Islet Sphingolipid Metabolism in Type 1 Diabetes Diabetologia. 07, 2018 | Pubmed ID: 29671030 The Role of NOD Mice in Type 1 Diabetes Research: Lessons from the Past and Recommendations for the Future Frontiers in Endocrinology. 2018 | Pubmed ID: 29527189 Nanodroplet Processing Platform for Deep and Quantitative Proteome Profiling of 10-100 Mammalian Cells Nature Communications. 02, 2018 | Pubmed ID: 29491378 Loss of B-Cell Anergy in Type 1 Diabetes Is Associated With High-Risk HLA and Non-HLA Disease Susceptibility Alleles Diabetes. 04, 2018 | Pubmed ID: 29343548 Mitochondrial Reactive Oxygen Species and Type 1 Diabetes Antioxidants & Redox Signaling. 11, 2018 | Pubmed ID: 29295631 Avidity and Bystander Suppressive Capacity of Human Regulatory T Cells Expressing Autoreactive T-Cell Receptors in Type 1 Diabetes Frontiers in Immunology. 2017 | Pubmed ID: 29123516 The Type 1 Diabetes-Resistance Locus Controls Trafficking of Autoreactive CTLs into the Pancreatic Islets of NOD Mice Journal of Immunology (Baltimore, Md. : 1950). 12, 2017 | Pubmed ID: 29109122 Type I Interferon Is a Catastrophic Feature of the Diabetic Islet Microenvironment Frontiers in Endocrinology. 2017 | Pubmed ID: 28959234 T Cells Display Mitochondria Hyperpolarization in Human Type 1 Diabetes Scientific Reports. 09, 2017 | Pubmed ID: 28883439 Type 1 Interferons Potentiate Human CD8 T-Cell Cytotoxicity Through a STAT4- and Granzyme B-Dependent Pathway Diabetes. 12, 2017 | Pubmed ID: 28877912 Mitochondrial ATP Transporter Depletion Protects Mice Against Liver Steatosis and Insulin Resistance Nature Communications. 02, 2017 | Pubmed ID: 28205519 Interferon-γ Limits Diabetogenic CD8 T-Cell Effector Responses in Type 1 Diabetes Diabetes. 03, 2017 | Pubmed ID: 27920091 Human Pancreatic Cancer Cells Induce a MyD88-Dependent Stromal Response to Promote a Tumor-Tolerant Immune Microenvironment Cancer Research. 02, 2017 | Pubmed ID: 27864347 Genetic Risk Analysis of a Patient with Fulminant Autoimmune Type 1 Diabetes Mellitus Secondary to Combination Ipilimumab and Nivolumab Immunotherapy Journal for Immunotherapy of Cancer. 2016 | Pubmed ID: 28031819 Islet-derived CD4 T-cells Targeting Proinsulin in Human Autoimmune Diabetes Diabetes. Dec, 2016 | Pubmed ID: 27920090 Antithymocyte Globulin Plus G-CSF Combination Therapy Leads to Sustained Immunomodulatory and Metabolic Effects in a Subset of Responders With Established Type 1 Diabetes Diabetes. Dec, 2016 | Pubmed ID: 27669730 Islet Cell Hyperexpression of HLA Class I Antigens: a Defining Feature in Type 1 Diabetes Diabetologia. 11, 2016 | Pubmed ID: 27506584 Liquid Chromatography-Mass Spectrometry Metabolic and Lipidomic Sample Preparation Workflow for Suspension-Cultured Mammalian Cells Using Jurkat T Lymphocyte Cells Journal of Proteomics & Bioinformatics. Jun, 2015 | Pubmed ID: 26401069 Respiration and Substrate Transport Rates As Well As Reactive Oxygen Species Production Distinguish Mitochondria from Brain and Liver BMC Biochemistry. Sep, 2015 | Pubmed ID: 26358560 Loss of NOX-Derived Superoxide Exacerbates Diabetogenic CD4 T-Cell Effector Responses in Type 1 Diabetes Diabetes. Dec, 2015 | Pubmed ID: 26269022 Acute Versus Progressive Onset of Diabetes in NOD Mice: Potential Implications for Therapeutic Interventions in Type 1 Diabetes Diabetes. Nov, 2015 | Pubmed ID: 26216853 Combination Therapy Reverses Hyperglycemia in NOD Mice With Established Type 1 Diabetes Diabetes. Nov, 2015 | Pubmed ID: 26185279 Distinct Differences in the Responses of the Human Pancreatic β-cell Line EndoC-βH1 and Human Islets to Proinflammatory Cytokines American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. Sep, 2015 | Pubmed ID: 26084699 Reply to Gurgul-Convey and Lenzen: Cytokines, Nitric Oxide, and β-cells The Journal of Biological Chemistry. Apr, 2015 | Pubmed ID: 26065037 How the Location of Superoxide Generation Influences the β-cell Response to Nitric Oxide The Journal of Biological Chemistry. Mar, 2015 | Pubmed ID: 25648890 TRIF-dependent Innate Immune Activation is Critical for Survival to Neonatal Gram-negative Sepsis Journal of Immunology (Baltimore, Md. : 1950). Feb, 2015 | Pubmed ID: 25548220 Association of the Mt-ND2 5178A/C Polymorphism with Parkinson's Disease Neuroscience Letters. Feb, 2015 | Pubmed ID: 25511548 Anti-thymocyte Globulin/G-CSF Treatment Preserves β Cell Function in Patients with Established Type 1 Diabetes The Journal of Clinical Investigation. Jan, 2015 | Pubmed ID: 25500887 Mechanisms of Tumor Necrosis Factor α Antagonist-induced Lupus in a Murine Model Arthritis & Rheumatology (Hoboken, N.J.). Jan, 2015 | Pubmed ID: 25252121 Metabolic Abnormalities in the Pathogenesis of Type 1 Diabetes Current Diabetes Reports. 2014 | Pubmed ID: 25023213 In Search of a Surrogate: Engineering Human Beta Cell Lines for Therapy Trends in Endocrinology and Metabolism: TEM. Aug, 2014 | Pubmed ID: 24958526 Use of Chemical Probes to Detect Mitochondrial ROS by Flow Cytometry and Spectrofluorometry Methods in Enzymology. 2014 | Pubmed ID: 24862269 Do β-cells Generate Peroxynitrite in Response to Cytokine Treatment? The Journal of Biological Chemistry. Dec, 2013 | Pubmed ID: 24194521 Comparative Genetics: Synergizing Human and NOD Mouse Studies for Identifying Genetic Causation of Type 1 Diabetes The Review of Diabetic Studies : RDS. 2012 | Pubmed ID: 23804259 Oxidative Stress and Beta Cell Dysfunction Methods in Molecular Biology (Clifton, N.J.). 2012 | Pubmed ID: 22933078 Immune-mediated β-cell Death in Type 1 Diabetes: Lessons from Human β-cell Lines European Journal of Clinical Investigation. Nov, 2012 | Pubmed ID: 22924552 Inherited β-cell Dysfunction in Lean Individuals with Type 2 Diabetes Diabetes. Jul, 2012 | Pubmed ID: 22723272 Pleiotropic IFN-dependent and -independent Effects of IRF5 on the Pathogenesis of Experimental Lupus Journal of Immunology (Baltimore, Md. : 1950). Apr, 2012 | Pubmed ID: 22422888 The Use of Leptin As Treatment for Type 1 Diabetes Mellitus: Counterpoint Pediatric Diabetes. Feb, 2012 | Pubmed ID: 21884562 Role of Genetics in Resistance to Type 1 Diabetes Diabetes/metabolism Research and Reviews. Nov, 2011 | Pubmed ID: 22069272 Increased Superoxide Accumulation in Pyruvate Dehydrogenase Complex Deficient Fibroblasts Molecular Genetics and Metabolism. Nov, 2011 | Pubmed ID: 21846590 Development of Diabetes in Lean Ncb5or-null Mice is Associated with Manifestations of Endoplasmic Reticulum and Oxidative Stress in Beta Cells Biochimica Et Biophysica Acta. Nov, 2011 | Pubmed ID: 21839170 Role of the Mitochondria in Immune-mediated Apoptotic Death of the Human Pancreatic β Cell Line βLox5 PloS One. 2011 | Pubmed ID: 21738580 Superoxide Production by Macrophages and T Cells is Critical for the Induction of Autoreactivity and Type 1 Diabetes Diabetes. Aug, 2011 | Pubmed ID: 21715554 Neutrophil Mobilization from the Bone Marrow During Polymicrobial Sepsis is Dependent on CXCL12 Signaling Journal of Immunology (Baltimore, Md. : 1950). Jul, 2011 | Pubmed ID: 21690321 Progressive Erosion of β-cell Function Precedes the Onset of Hyperglycemia in the NOD Mouse Model of Type 1 Diabetes Diabetes. Aug, 2011 | Pubmed ID: 21659497 Critical Role for CXC Ligand 10/CXC Receptor 3 Signaling in the Murine Neonatal Response to Sepsis Infection and Immunity. Jul, 2011 | Pubmed ID: 21518789 Sepsis Induces Early Alterations in Innate Immunity That Impact Mortality to Secondary Infection Journal of Immunology (Baltimore, Md. : 1950). Jan, 2011 | Pubmed ID: 21106855 Mt-Nd2(a) Modifies Resistance Against Autoimmune Type 1 Diabetes in NOD Mice at the Level of the Pancreatic β-cell Diabetes. Jan, 2011 | Pubmed ID: 20980458 NADPH Oxidase Deficiency Regulates Th Lineage Commitment and Modulates Autoimmunity Journal of Immunology (Baltimore, Md. : 1950). Nov, 2010 | Pubmed ID: 20881184 Use of Nonobese Diabetic Mice to Understand Human Type 1 Diabetes Endocrinology and Metabolism Clinics of North America. Sep, 2010 | Pubmed ID: 20723819 Immune Depletion with Cellular Mobilization Imparts Immunoregulation and Reverses Autoimmune Diabetes in Nonobese Diabetic Mice Diabetes. Oct, 2009 | Pubmed ID: 19628781 Evaluating Protocols for Embryonic Stem Cell Differentiation into Insulin-secreting Beta-cells Using Insulin II-GFP As a Specific and Noninvasive Reporter Cloning and Stem Cells. Jun, 2009 | Pubmed ID: 19508115 Role of SREBP-1 in the Development of Parasympathetic Dysfunction in the Hearts of Type 1 Diabetic Akita Mice Circulation Research. Jul, 2009 | Pubmed ID: 19423844 Chapter 24 Quantification, Localization, and Tissue Specificities of Mouse Mitochondrial Reactive Oxygen Species Production Methods in Enzymology. 2009 | Pubmed ID: 19348903 MerTK Regulates Thymic Selection of Autoreactive T Cells Proceedings of the National Academy of Sciences of the United States of America. Mar, 2009 | Pubmed ID: 19251650 Role of Increased ROS Dissipation in Prevention of T1D Annals of the New York Academy of Sciences. Dec, 2008 | Pubmed ID: 19120287 Commonalities of Genetic Resistance to Spontaneous Autoimmune and Free Radical--mediated Diabetes Free Radical Biology & Medicine. Nov, 2008 | Pubmed ID: 18718526 Mt-Nd2a Suppresses Reactive Oxygen Species Production by Mitochondrial Complexes I and III The Journal of Biological Chemistry. Apr, 2008 | Pubmed ID: 18281288 MerTK is Required for Apoptotic Cell-induced T Cell Tolerance The Journal of Experimental Medicine. Jan, 2008 | Pubmed ID: 18195070 Autoreactive T-cell Responses: New Technology in Pursuit of an Old Nemesis Pediatric Diabetes. Oct, 2007 | Pubmed ID: 17850466 Nuclear and Mitochondrial Interaction Involving Mt-Nd2 Leads to Increased Mitochondrial Reactive Oxygen Species Production The Journal of Biological Chemistry. Feb, 2007 | Pubmed ID: 17189252 Apoptotic Cells Induce Mer Tyrosine Kinase-dependent Blockade of NF-kappaB Activation in Dendritic Cells Blood. Jan, 2007 | Pubmed ID: 17008547 Modulatory Role of DR4- to DQ8-restricted CD4 T-cell Responses and Type 1 Diabetes Susceptibility Diabetes. Dec, 2006 | Pubmed ID: 17130492 HLA-A*0201-restricted T Cells from Humanized NOD Mice Recognize Autoantigens of Potential Clinical Relevance to Type 1 Diabetes Journal of Immunology (Baltimore, Md. : 1950). Mar, 2006 | Pubmed ID: 16493087 Utility of Murine Models for the Study of Spontaneous Autoimmune Type 1 Diabetes Pediatric Diabetes. Sep, 2005 | Pubmed ID: 16109074 Mechanisms Underlying Resistance of Pancreatic Islets from ALR/Lt Mice to Cytokine-induced Destruction Journal of Immunology (Baltimore, Md. : 1950). Jul, 2005 | Pubmed ID: 16002729 Major Histocompatibility Complex-linked Diabetes Susceptibility in NOD/Lt Mice: Subcongenic Analysis Localizes a Component of Idd16 at the H2-D End of the Diabetogenic H2(g7) Complex Diabetes. May, 2005 | Pubmed ID: 15855353 Proteasome Inhibition Alters Glucose-stimulated (pro)insulin Secretion and Turnover in Pancreatic {beta}-cells The Journal of Biological Chemistry. Apr, 2005 | Pubmed ID: 15705591 ALS/Lt: a New Type 2 Diabetes Mouse Model Associated with Low Free Radical Scavenging Potential Diabetes. Feb, 2004 | Pubmed ID: 14749277 Genetic Analysis of Resistance to Type-1 Diabetes in ALR/Lt Mice, a NOD-related Strain with Defenses Against Autoimmune-mediated Diabetogenic Stress Immunogenetics. Oct, 2003 | Pubmed ID: 14513297 Rodent Models for the Study of Type 2 Diabetes in Children (juvenile Diabesity) Pediatric Diabetes. Sep, 2002 | Pubmed ID: 15016157 New Mouse Model to Study Islet Transplantation in Insulin-dependent Diabetes Mellitus Transplantation. Apr, 2002 | Pubmed ID: 11981430 Genetic Control of Neutrophil Superoxide Production in Diabetes-resistant ALR/Lt Mice Free Radical Biology & Medicine. Apr, 2002 | Pubmed ID: 11937300 Observing Islet Function and Islet-Immune Cell Interactions in Live Pancreatic Tissue Slices Mollie K. Huber1, Denise M. Drotar2,3,4, Helmut Hiller1, Maria L. Beery1, Paul Joseph1, Irina Kusmartseva1, Stephan Speier2,3,4, Mark A. Atkinson1, Clayton E. Mathews1, Edward A. Phelps5 1Department of Pathology, Immunology, and Laboratory Medicine, University of Florida, 2Paul Langerhans Institute Dresden (PLID) of the Helmholtz Zentrum München at the University Clinic Carl Gustav Carus of Technische Universität Dresden, 3Institute of Physiology, Faculty of Medicine, Technische Universität Dresden, 4German Center for Diabetes Research (DZD), 5J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida JoVE 62207 Immunologia e infezioni Methods to Assess Beta Cell Death Mediated by Cytotoxic T Lymphocytes Jing Chen1, Scott Grieshaber1, Clayton E. Mathews1 1Departments of Pathology, Immunology and Laboratory Medicine, College of Medicine, University of Florida JoVE 2724 Immunologia e infezioni
Observing Islet Function and Islet-Immune Cell Interactions in Live Pancreatic Tissue Slices Mollie K. Huber1, Denise M. Drotar2,3,4, Helmut Hiller1, Maria L. Beery1, Paul Joseph1, Irina Kusmartseva1, Stephan Speier2,3,4, Mark A. Atkinson1, Clayton E. Mathews1, Edward A. Phelps5 1Department of Pathology, Immunology, and Laboratory Medicine, University of Florida, 2Paul Langerhans Institute Dresden (PLID) of the Helmholtz Zentrum München at the University Clinic Carl Gustav Carus of Technische Universität Dresden, 3Institute of Physiology, Faculty of Medicine, Technische Universität Dresden, 4German Center for Diabetes Research (DZD), 5J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida JoVE 62207 Immunologia e infezioni
Methods to Assess Beta Cell Death Mediated by Cytotoxic T Lymphocytes Jing Chen1, Scott Grieshaber1, Clayton E. Mathews1 1Departments of Pathology, Immunology and Laboratory Medicine, College of Medicine, University of Florida JoVE 2724 Immunologia e infezioni