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A Model for Epilepsy of Infectious Etiology using Theiler’s Murine Encephalomyelitis Virus
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Neurosciences
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Journal JoVE Neurosciences
A Model for Epilepsy of Infectious Etiology using Theiler’s Murine Encephalomyelitis Virus

A Model for Epilepsy of Infectious Etiology using Theiler’s Murine Encephalomyelitis Virus

2,332 Views

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05:33 min

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June 23, 2022

DOI:

10.3791/63673-v

DOI:
10.3791/63673-v

•

05:33 min
June 23, 2022

•

10 Views
, , , , ,
1Department of Pharmacology and Toxicology,University of Utah, 2Interdepartmental Program in Neuroscience,University of Utah, 3Faculty of Veterinary Medicine, Institute of Pharmacology and Toxicology,Freie Universität Berlin

Summary

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Intracerebral infection with the Theiler's murine encephalomyelitis virus (TMEV) in C57BL/6 mice replicates many of the early and chronic clinical symptoms of viral encephalitis and subsequent epilepsy in human patients. This paper describes the virus infection, symptoms, and histopathology of the TMEV model.

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Cite this Article

Batot, G., Metcalf, C. S., Bell, L. A., Pauletti, A., Wilcox, K. S., Bröer, S. A Model for Epilepsy of Infectious Etiology using Theiler's Murine Encephalomyelitis Virus. J. Vis. Exp. (184), e63673, doi:10.3791/63673 (2022).

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