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Biochemistry

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Workflow and Tools for Crystallographic Fragment Screening at the Helmholtz-Zentrum Berlin
 

Workflow and Tools for Crystallographic Fragment Screening at the Helmholtz-Zentrum Berlin

Article DOI: 10.3791/62208-v • 06:29 min • March 3rd, 2021
March 3rd, 2021 •
1, 1,2, 3, 4, 5, 3, 1,4, 1, 1, 1, 1, 1, 1, 4, 4, 1, 1
1Macromolecular Crystallography, Helmholtz-Zentrum Berlin, 2Structural Biochemistry Group, Institute for Chemistry and Biochemistry, Freie Universität Berlin, 3BioMAX, MAX IV Laboratory, 4Drug Design Group, Institute of Pharmaceutical Chemistry, Philipps-Universität Marburg, 5Department Sample Environment, Helmholtz-Zentrum Berlin

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Crystallographic fragment screening at the Helmholtz-Zentrum Berlin is performed using a workflow with dedicated compound libraries, crystal handling tools, fast data collection facilities and largely automated data analysis. The presented protocol intends to maximize the output of such experiments to provide promising starting points for downstream structure-based ligand design.

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Workflow Tools Crystallographic Fragment Screening Helmholtz-Zentrum Berlin X-ray Crystallography Organic Compounds Drug Discovery Biochemical Tool Compound Development Protein Binding Protein Crystals Sample Handling Visual Demonstration Tatjana Barthel Doctoral Researcher PhD Student Screening Plate Soaking Solution Reagent Reservoir Easy Access Frame Microscope
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