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小鼠的转宫胎儿气管闭塞模型

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Biologie du développement

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Journal JoVE Biologie du développement

Transuterine Fetal Tracheal Occlusion Model in Mice

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小鼠的转宫胎儿气管闭塞模型

2,846 Views

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06:31 min

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February 05, 2021

DOI:

10.3791/61772-v

DOI:

10.3791/61772-v

•

06:31 min

February 05, 2021

•

3 Views

Emrah Aydın^1,2, Rashika Joshi³, Marc Oria¹, Foong-Yen Lim¹, Brian Michael Varisco³, Jose Luis Peiro¹

¹The Center for Fetal, Cellular & Molecular Therapy, Cincinnati Fetal Center, Division of Pediatric General and Thoracic Surgery,Cincinnati Children’s Hospital Medical Center, ²Department of Pediatric Surgery,Tekirdag Namik Kemal University School of Medicine, ³The Division of Critical Care Medicine, Department of Pediatrics,Cincinnati Children’s Hospital Medical Center

Summary

各种先天性隔膜气喘和胎儿气管闭塞的动物模型在伦理问题、成本、手术难度、大小、存活率和遗传工具的可用性方面都存在利弊。该模型为研究气管闭塞和增加的发光压力对肺发育的影响提供了新的工具。

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