Contribution of the Na<sup>+</sup>/K<sup>+</sup> Pump to Rhythmic Bursting, Explored with Modeling and Dynamic Clamp Analyses

Ricardo  Javier Erazo-Toscano; Parker  J. Ellingson; Ronald  L. Calabrese; Gennady  S. Cymbalyuk

doi:10.3791/61473

Journal

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Biologie

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Contribution of the Na⁺/K⁺ Pump to Rhythmic Bursting, Explored with Modeling and Dynamic Clamp Analyses

Journal JoVE
Biologie

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Journal JoVE Biologie

Contribution of the Na⁺/K⁺ Pump to Rhythmic Bursting, Explored with Modeling and Dynamic Clamp Analyses

2,463 Views

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08:34 min

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May 09, 2021

DOI:

10.3791/61473-v

DOI:

10.3791/61473-v

•

08:34 min

May 09, 2021

•

11 Views

Ricardo Javier Erazo-Toscano^1,2, Parker J. Ellingson², Ronald L. Calabrese*¹, Gennady S. Cymbalyuk*²

¹Department of Biology,Emory University, ²Neuroscience Institute,Georgia State University

Summary

Presented here is a method for investigation of the roles of the Na⁺/K⁺ pump and persistent Na⁺ current in leech heart interneurons using dynamic clamp.

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Contribution of the Na+/K+ Pump to Rhythmic Bursting, Explored with Modeling and Dynamic Clamp Analyses

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Contribution of the Na⁺/K⁺ Pump to Rhythmic Bursting, Explored with Modeling and Dynamic Clamp Analyses