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生成用于发育和疾病建模应用的 hiPSC 衍生肠道类器官
Journal JoVE
Biologie
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Journal JoVE Biologie
Generation of hiPSC-Derived Intestinal Organoids for Developmental and Disease Modelling Applications
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生成用于发育和疾病建模应用的 hiPSC 衍生肠道类器官

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06:34 min

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March 08, 2024

DOI:

10.3791/61199-v

DOI:
10.3791/61199-v

•

06:34 min
March 08, 2024

•

10 Views
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1Biodiscovery Institute, Translational Medical Sciences, School of Medicine,University of Nottingham

Summary

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该协议允许将人类多能细胞分化为肠道类器官。该协议通过将细胞分化为确定的内胚层，后肠内胚层和肠上皮细胞群来模拟正常的人类发育。这使得该协议适用于研究肠道发育和疾病建模应用。

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Cite this Article

Durczak, P. M., Fair, K. L., Jinks, N., Cuevas Ocaña, S., Sainz Zuñiga, C. B., Hannan, N. R. Generation of hiPSC-Derived Intestinal Organoids for Developmental and Disease Modelling Applications. J. Vis. Exp. (205), e61199, doi:10.3791/61199 (2024).

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