Journal
/
Neurosciences
/
3D Modeling of Dendritic Spines with Synaptic Plasticity
Journal JoVE
Neurosciences
Un abonnement à JoVE est nécessaire pour voir ce contenu.  Connectez-vous ou commencez votre essai gratuit.
Journal JoVE Neurosciences
3D Modeling of Dendritic Spines with Synaptic Plasticity

3D Modeling of Dendritic Spines with Synaptic Plasticity

DOI:
10.3791/60896-v

•

07:13 min

•

May 18, 2020

•

,
1Center for Mathematics, Computation and Cognition,Federal University of ABC

Chapitres

  • 00:04Introduction
  • 00:39Single Dendrite Spine Creation
  • 02:47Multiple Spine Dendrite Creation
  • 03:57Molecule Creation and Model Output Planning
  • 04:41Simulation
  • 05:42Results: Representative 3D Dendritic Spine Modeling
  • 06:36Conclusion

Summary

Traduction automatique

Traduction automatique

The protocol develops a three-dimensional (3D) model of a dendritic segment with dendritic spines for modeling synaptic plasticity. The constructed mesh can be used for computational modeling of AMPA receptor trafficking in the long-term synaptic plasticity using the software program Blender with CellBlender and MCell.

Tags

Keywords: 3D ModelingDendritic SpinesSynaptic PlasticityComputational ModelingMesh GenerationBlenderCellBlenderSpine HeadSpine NeckCylinderDendrite

Article

Embed

AJOUTER À LA PLAYLIST

Usage Statistics

Vidéos Connexes

check_url/fr/60896?article_type=v

Preparation of Oligomeric β-amyloid1-42 and Induction of Synaptic Plasticity Impairment on Hippocampal Slices
check_url/fr/60896?article_type=v

Fluorescence Recovery After Photobleaching (FRAP) of Fluorescence Tagged Proteins in Dendritic Spines of Cultured Hippocampal Neurons
check_url/fr/60896?article_type=v

Lateral Diffusion and Exocytosis of Membrane Proteins in Cultured Neurons Assessed using Fluorescence Recovery and Fluorescence-loss Photobleaching
check_url/fr/60896?article_type=v

Voltage-sensitive Dye Recording from Axons, Dendrites and Dendritic Spines of Individual Neurons in Brain Slices
check_url/fr/60896?article_type=v

Visualizing the Effects of a Positive Early Experience, Tactile Stimulation, on Dendritic Morphology and Synaptic Connectivity with Golgi-Cox Staining
check_url/fr/60896?article_type=v

Fast Micro-iontophoresis of Glutamate and GABA: A Useful Tool to Investigate Synaptic Integration
check_url/fr/60896?article_type=v

Deriving the Time Course of Glutamate Clearance with a Deconvolution Analysis of Astrocytic Transporter Currents
check_url/fr/60896?article_type=v

Imaging Dendritic Spines of Rat Primary Hippocampal Neurons using Structured Illumination Microscopy
check_url/fr/60896?article_type=v

Two-Photon in vivo Imaging of Dendritic Spines in the Mouse Cortex Using a Thinned-skull Preparation
check_url/fr/60896?article_type=v

Pentylenetetrazole-Induced Kindling Mouse Model

Read Article