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Establishment of a Severe Dry Eye Model Using Complete Dacryoadenectomy in Rabbits
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Médecine
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Journal JoVE Médecine
Establishment of a Severe Dry Eye Model Using Complete Dacryoadenectomy in Rabbits

Establishment of a Severe Dry Eye Model Using Complete Dacryoadenectomy in Rabbits

9,657 Views

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07:43 min

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January 08, 2020

DOI:

10.3791/60126-v

DOI:
10.3791/60126-v

•

07:43 min
January 08, 2020

•

3 Views
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1Department of Ophthalmology,Stony Brook University, 2Department of Medicine,Stony Brook University, 3Medicon Pharmaceuticals, Inc, 4Department of Preventive Medicine,Stony Brook University

Summary

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A novel approach is presented to induce chronic dry eye disease in rabbits by surgically removing all orbital lacrimal glands. This method, distinct from those previously reported, produces a stable, reproducible model of aqueous deficient dry eye well suited to study tear physiology and pathophysiology and ocular therapeutics.

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Severe Dry EyeDacryoadenectomyRabbit ModelAqueous Deficient Dry EyeLacrimal Gland RemovalNictitating MembraneOrbital Superior Lacrimal GlandSurgical TechniqueSurgical AnatomyOphthalmology Research

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Cite this Article

Honkanen, R. A., Huang, L., Huang, W., Rigas, B. Establishment of a Severe Dry Eye Model Using Complete Dacryoadenectomy in Rabbits. J. Vis. Exp. (155), e60126, doi:10.3791/60126 (2020).

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