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Neuroscience

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JoVE Journal Neuroscience
Chronic Implantation of Multiple Flexible Polymer Electrode Arrays
 

Chronic Implantation of Multiple Flexible Polymer Electrode Arrays

Article DOI: 10.3791/59957-v • 08:54 min • October 4th, 2019
October 4th, 2019 •
*1,2, *1,2, 2, 3, 2, 2, 3, 2, 4,5, 4, 4, 4, 4,5, 2,6
1Medical Scientist Training Program and Neuroscience Graduate Program, University of California San Francisco, 2Kavli Institute for Fundamental Neuroscience, Center for Integrative Neuroscience, and Department of Physiology, University of California San Francisco, 3Bioengineering Graduate Program, University of California San Francisco, 4Center for Micro- and Nanotechnology, Lawrence Livermore National Laboratory, 5Neuralink Corp., 6Howard Hughes Medical Institute
* These authors contributed equally

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Described below is a method for implantation of multiple polymer electrode arrays across anatomically distant brain regions for chronic electrophysiological recording in freely moving rats. Preparation and surgical implantation are described in detail, with emphasis on design principles to guide adaptation of these methods for use in other species.

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