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Middle Cerebral Artery Occlusion Allowing Reperfusion via Common Carotid Artery Repair in Mice
 

Middle Cerebral Artery Occlusion Allowing Reperfusion via Common Carotid Artery Repair in Mice

Article DOI: 10.3791/58191-v • 06:59 min • January 23rd, 2019
January 23rd, 2019 •
1, 2, 2, 1,3
1Department of Neuroscience, Psychology and Behaviour, University of Leicester, 2Preclinical Imaging Facility, Core Biotechnology Services, University of Leicester, 3School of Psychology, University of Nottingham

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Intraluminal filament occlusion of the middle cerebral artery is the most frequently used in vivo model of experimental stroke in rodents. An alternative surgical approach to allow common carotid artery repair is performed here, which allows the reperfusion of the common carotid artery and a full reperfusion to the middle cerebral artery territory.

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Middle Cerebral Artery Occlusion Reperfusion Common Carotid Artery Repair Mice Experimental Stroke Field Reduce Variability Improve Reproducibility Technique Re-perfusion Circle Of Willis Anatomical Variation Experimental Outcome Measures CCA Vessel Repair Steps Visual Demonstration Technical Difficulty Anesthetize Mouse Scalpel Blade Midline Incision Ventral Neck Blunt Dissection Techniques Salivary Glands Trachea Dissect CCA Non-dissolvable 6-0 Suture Silk Tie Internal Carotid Artery
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