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由亲炎细胞因子的内脑注射诱导的广度脑皮质脱叶的鼠模型
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September 21, 2021
DOI:
1Research Unit of Experimental Neurotraumatology, Department of Neurosurgery,Medical University Graz, 2Department of Neurology,Medical University Graz, 3Centre for Molecular Medicine, Department of Clinical Neuroscience,Karolinska Institutet, 4Division of Vascular Biology, Department of Medical Biochemistry and Biophysics,Karolinska Institutet
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这里提出的协议允许成年雄性黑阿古提大鼠的皮质半球广泛脱皮。该方法包括导管的内腔植入、骨髓寡细胞糖蛋白的亚临床免疫，以及通过植入导管对促炎细胞因子混合物的内腔注射。
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Üçal, M., Haindl, M. T., Adzemovic, M. Z., Zeitelhofer, M., Schaefer, U., Fazekas, F., Hochmeister, S. Rat Model of Widespread Cerebral Cortical Demyelination Induced by an Intracerebral Injection of Pro-Inflammatory Cytokines. J. Vis. Exp. (175), e57879, doi:10.3791/57879 (2021).
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