This protocol describes a behavioral assay, based on the Barnes maze test, to study how instinctive defensive actions are modified by the knowledge of spatial environment.
Vale, R., Evans, D., Branco, T. A Behavioral Assay for Investigating the Role of Spatial Memory During Instinctive Defense in Mice. J. Vis. Exp. (137), e56988, doi:10.3791/56988 (2018).