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Developmental Biology

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JoVE Journal Developmental Biology
Assessment of the Effects of Endocrine Disrupting Compounds on the Development of Vertebrate Neural Network Function Using Multi-electrode Arrays
 

Assessment of the Effects of Endocrine Disrupting Compounds on the Development of Vertebrate Neural Network Function Using Multi-electrode Arrays

Article DOI: 10.3791/56300-v • 08:28 min • April 26th, 2018
April 26th, 2018 •
1, 1, 1, 1
1Department of Biological Sciences, Delaware State University

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Exposure to environmental toxins can acutely impact developing embryos. Endocrine disrupting chemicals such as bisphenols are known to adversely affect the nervous system. Here we describe a protocol using an in vitro vertebrate (chick embryo) neuronal network model to study the functional impact of toxin exposure on early embryos.

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Endocrine Disrupting Compounds Bisphenols Multi-electrode Arrays Network Spiking Activity Vertebrate Neuronal Networks Developmental Neurobiology Environmental Toxicology Mean Firing Rate Total Number Of Spikes Spike Amplitude Synchrony Neuron Plating Extracellular Matrix Neurobasal Medium
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