A wireless, bidirectional system for multi-channel neural recordings and stimulation in freely behaving rats is introduced. The system is light and compact, thus having minimal impact on the animal´s behavioral repertoire. Moreover, this bidirectional system provides a sophisticated tool to assess causal relationships between brain activation patterns and behavior.
Melo-Thomas, L., Engelhardt, K., Thomas, U., Hoehl, D., Thomas, S., Wöhr, M., Werner, B., Bremmer, F., Schwarting, R. K. A Wireless, Bidirectional Interface for In Vivo Recording and Stimulation of Neural Activity in Freely Behaving Rats. J. Vis. Exp. (129), e56299, doi:10.3791/56299 (2017).