Journal
/
Immunologie et infection
/
Inductie van verlamming en visuele systeem schade in muizen door T cellen specifiek voor Neuromyelitis Optica Autoantigen Aquaporin-4
Journal JoVE
Immunologie et infection
This content is Free Access.
Journal JoVE Immunologie et infection
Induction of Paralysis and Visual System Injury in Mice by T Cells Specific for Neuromyelitis Optica Autoantigen Aquaporin-4
Please note that all translations are automatically generated. Click here for the English version.

Inductie van verlamming en visuele systeem schade in muizen door T cellen specifiek voor Neuromyelitis Optica Autoantigen Aquaporin-4

10,970 Views

•

09:29 min

•

August 21, 2017

DOI:

10.3791/56185-v

DOI:
10.3791/56185-v

•

09:29 min
August 21, 2017

•

1 Views
, , , , , , ,
1Department of Neurology,University of California, 2Program in Immunology,University of California, 3Department of Neurology and Neurological Sciences,Stanford University, 4Department of Pathology,Stanford University

Summary

Automatically generated

Hier presenteren we een protocol om te veroorzaken verlamming en opticospinal ontsteking door overdracht van aquaporin-4 (AQP4)-specifieke T-cellen van de AQP4- / - muizen in WT muizen. Daarnaast tonen we hoe met seriële optische coherentie tomografie controleren visuele systeem dysfunctie.

Explore More Videos

Neuromyelitis OpticaAquaporin-4T CellsAdoptive TransferCentral Nervous System Autoimmune DiseaseOptical Coherence TomographyRetinal InjuryComplete Freund’s AdjuvantEmulsionSubcutaneous Injection

Read Article

Cite this Article

Sagan, S. A., Cruz-Herranz, A., Spencer, C. M., Ho, P. P., Steinman, L., Green, A. J., Sobel, R. A., Zamvil, S. S. Induction of Paralysis and Visual System Injury in Mice by T Cells Specific for Neuromyelitis Optica Autoantigen Aquaporin-4. J. Vis. Exp. (126), e56185, doi:10.3791/56185 (2017).

Download .ris file

Copy

Share Video

.

Copy